Rüeger, Sina; Hammer, Christian; Loetscher, Alexis; McLaren, Paul J; Lawless, Dylan; Naret, Olivier; Khanna, Nina; Bernasconi, Enos; Cavassini, Matthias; Günthard, Huldrych F; Kahlert, Christian R; Rauch, Andri; Depledge, Daniel P; Morfopoulou, Sofia; Breuer, Judith; Zdobnov, Evgeny; Fellay, Jacques (2021). The influence of human genetic variation on Epstein-Barr virus sequence diversity. Scientific reports, 11(1), p. 4586. Springer Nature 10.1038/s41598-021-84070-7
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Epstein-Barr virus (EBV) is one of the most common viruses latently infecting humans. Little is known about the impact of human genetic variation on the large inter-individual differences observed in response to EBV infection. To search for a potential imprint of host genomic variation on the EBV sequence, we jointly analyzed paired viral and human genomic data from 268 HIV-coinfected individuals with CD4 + T cell count < 200/mm3 and elevated EBV viremia. We hypothesized that the reactivated virus circulating in these patients could carry sequence variants acquired during primary EBV infection, thereby providing a snapshot of early adaptation to the pressure exerted on EBV by the individual immune response. We searched for associations between host and pathogen genetic variants, taking into account human and EBV population structure. Our analyses revealed significant associations between human and EBV sequence variation. Three polymorphic regions in the human genome were found to be associated with EBV variation: one at the amino acid level (BRLF1:p.Lys316Glu); and two at the gene level (burden testing of rare variants in BALF5 and BBRF1). Our findings confirm that jointly analyzing host and pathogen genomes can identify sites of genomic interactions, which could help dissect pathogenic mechanisms and suggest new therapeutic avenues.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Rauch, Andri |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Annelies Luginbühl |
Date Deposited: |
11 May 2021 11:17 |
Last Modified: |
05 Dec 2022 15:51 |
Publisher DOI: |
10.1038/s41598-021-84070-7 |
PubMed ID: |
33633271 |
BORIS DOI: |
10.48350/156061 |
URI: |
https://boris.unibe.ch/id/eprint/156061 |
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