Takayasu arteritis: Prevalence and clinical presentation in Switzerland.

Gloor, Andrea D.; Chollet, Laurève; Christ, Lisa A.; Cullmann, Jennifer L.; Bonel, Harald M.; Villiger, Peter M. (2021). Takayasu arteritis: Prevalence and clinical presentation in Switzerland. PLoS ONE, 16(6), e0250025. Public Library of Science 10.1371/journal.pone.0250025

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OBJECTIVE

Takayasu arteritis (TAK) is a rare immune-mediated vasculitis of the aorta and its branches. Aims were to calculate prevalence and incidence in Switzerland, to assess disease activity and performance of MR-Angiography (MRA).

METHODS

31 patients were recorded in a database, 27 were followed prospectively up to 3 years. Prevalence was calculated based on data of the national statistical bureau. Disease activity was defined using the revised EULAR criteria. MRA depicted stenotic changes and aortic wall enhancement.

RESULTS

A disease prevalence of 14.5/1.000.000 inhabitants and an incidence of 0.3/1.000.000 per year was calculated. Aortic wall enhancement was found in 10 patients while in clinical and serological remission. EULAR criteria missed 5 patients with disease activity with isolated elevations of ESR/CRP. Arterial stenosis did not change over time in 5 cases, it improved in 2 and increased in 7. At follow-up 16 patients were treated with tocilizumab, 11/16 in monotherapy, 5 patients were treatment-free, 25/27 stayed in remission.

CONCLUSION

In addition to prevalence and incidence, our data show that MRA qualifies to detect subclinical disease activity, but, on the other hand, that EULAR criteria may miss disease activity in case of isolated elevation of ESR/CRP.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Gloor, Andrea Daniela; Chollet, Laurève Mélisande; Christ, Lisa Alexandra; Cullmann, Jennifer; Bonel, Harald Marcel and Villiger, Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1932-6203

Publisher:

Public Library of Science

Language:

English

Submitter:

Maria de Fatima Henriques Bernardo

Date Deposited:

29 Jun 2021 11:24

Last Modified:

04 Jul 2021 03:08

Publisher DOI:

10.1371/journal.pone.0250025

PubMed ID:

34143786

BORIS DOI:

10.48350/157012

URI:

https://boris.unibe.ch/id/eprint/157012

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