Gloor, Andrea D.; Chollet, Laurève; Christ, Lisa A.; Cullmann, Jennifer L.; Bonel, Harald M.; Villiger, Peter M. (2021). Takayasu arteritis: Prevalence and clinical presentation in Switzerland. PLoS ONE, 16(6), e0250025. Public Library of Science 10.1371/journal.pone.0250025
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OBJECTIVE
Takayasu arteritis (TAK) is a rare immune-mediated vasculitis of the aorta and its branches. Aims were to calculate prevalence and incidence in Switzerland, to assess disease activity and performance of MR-Angiography (MRA).
METHODS
31 patients were recorded in a database, 27 were followed prospectively up to 3 years. Prevalence was calculated based on data of the national statistical bureau. Disease activity was defined using the revised EULAR criteria. MRA depicted stenotic changes and aortic wall enhancement.
RESULTS
A disease prevalence of 14.5/1.000.000 inhabitants and an incidence of 0.3/1.000.000 per year was calculated. Aortic wall enhancement was found in 10 patients while in clinical and serological remission. EULAR criteria missed 5 patients with disease activity with isolated elevations of ESR/CRP. Arterial stenosis did not change over time in 5 cases, it improved in 2 and increased in 7. At follow-up 16 patients were treated with tocilizumab, 11/16 in monotherapy, 5 patients were treatment-free, 25/27 stayed in remission.
CONCLUSION
In addition to prevalence and incidence, our data show that MRA qualifies to detect subclinical disease activity, but, on the other hand, that EULAR criteria may miss disease activity in case of isolated elevation of ESR/CRP.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Gloor, Andrea Daniela, Chollet, Laurève Mélisande, Christ, Lisa Alexandra, Cullmann, Jennifer, Bonel, Harald Marcel, Villiger, Peter Matthias |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1932-6203 |
Publisher: |
Public Library of Science |
Language: |
English |
Submitter: |
Maria de Fatima Henriques Bernardo |
Date Deposited: |
29 Jun 2021 11:24 |
Last Modified: |
05 Dec 2022 15:51 |
Publisher DOI: |
10.1371/journal.pone.0250025 |
PubMed ID: |
34143786 |
BORIS DOI: |
10.48350/157012 |
URI: |
https://boris.unibe.ch/id/eprint/157012 |
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