Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases.

Thakur, Manovriti; Evans, Bryce; Schindewolf, Marc; Baumgartner, Iris; Döring, Yvonne (2021). Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases. Cells, 10(7) MDPI 10.3390/cells10071689

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Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils. NETs participate in host immune defense by entrapping pathogens. They are pro-inflammatory in function, and they act as an initiator of vascular coagulopathies by providing a platform for the attachment of various coagulatory proteins. NETs are diverse in their ability to alter physiological and pathological processes including infection and inflammation. In this review, we will summarize recent findings on the role of NETs in bacterial/viral infections associated with vascular inflammation, thrombosis, atherosclerosis and autoimmune disorders. Understanding the complex role of NETs in bridging infection and chronic inflammation as well as discussing important questions related to their contribution to pathologies outlined above may pave the way for future research on therapeutic targeting of NETs applicable to specific infections and inflammatory disorders.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology

UniBE Contributor:

Thakur, Manovriti; Evans, Bryce Ridley; Schindewolf, Marc; Baumgartner, Iris and Döring, Yvonne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2073-4409

Publisher:

MDPI

Language:

English

Submitter:

Rebecca Scheidegger

Date Deposited:

26 Aug 2021 11:58

Last Modified:

26 Aug 2021 11:58

Publisher DOI:

10.3390/cells10071689

PubMed ID:

34359859

Uncontrolled Keywords:

CVD NETs atherosclerosis autoimmune diseases infection inflammation thrombosis

BORIS DOI:

10.48350/157977

URI:

https://boris.unibe.ch/id/eprint/157977

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