Ontsouka, Edgar; Lüthi, Michael; Zaugg, Jonas; Schroeder, Mariana; Albrecht, Christiane (2021). Establishment and validation of an approach allowing unequivocal fetal sex determination based on placental sex-specific genes. Placenta, 112, pp. 132-134. Elsevier 10.1016/j.placenta.2021.07.295
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The use of human placenta as a matrix for the prediction of the baby's sex has been recently documented, but evaluation methods for placental sex-determining genes allowing reliable sex prediction are still lacking. We compared the accuracy of the retrospective prediction of the baby's sex using placental mRNA expression of RPS4Y1, DDX3Y, and XIST analyzed by an already reported method and a newly developed evaluation approach. Full concordance between the predicted and the actual baby sex was only obtained when analyzing placental RPS4Y1 expression with the newly proposed method, which was found to be robust and reliable.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Ontsouka, Corneille Edgar, Lüthi, Michael, Zaugg, Jonas, Schröder, Mariana, Albrecht, Christiane |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0143-4004 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Barbara Franziska Järmann-Bangerter |
Date Deposited: |
09 Sep 2021 09:40 |
Last Modified: |
02 Mar 2023 23:35 |
Publisher DOI: |
10.1016/j.placenta.2021.07.295 |
PubMed ID: |
34339973 |
Uncontrolled Keywords: |
Fetal sex Gene expression Human placenta Pregnancy complications Sex-specific genes |
BORIS DOI: |
10.48350/158324 |
URI: |
https://boris.unibe.ch/id/eprint/158324 |
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