Respiratory symptoms do not reflect functional impairment in early CF lung disease.

Korten, Insa; Oestreich, Marc-Alexander; Frey, Urs; Moeller, Alexander; Jung, Andreas; Spinas, Renate; Mueller-Suter, Dominik; Trachsel, Daniel; Rochat, Isabelle; Spycher, Ben; Latzin, Philipp; Casaulta, Carmen; Ramsey, Kathryn (2021). Respiratory symptoms do not reflect functional impairment in early CF lung disease. (In Press). Journal of cystic fibrosis Elsevier 10.1016/j.jcf.2021.04.006

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BACKGROUND

Lung disease can develop within the first year of life in infants with cystic fibrosis (CF). However, the frequency and severity of respiratory symptoms in infancy are not known.

METHODS

We assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life.

RESULTS

We analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p=0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms.

CONCLUSIONS

We found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Korten, Insa Christina Severine; Oestreich, Marc-Alexander Heinz; Spycher, Ben; Latzin, Philipp; Casaulta, Carmen and Ramsey, Kathryn Angela

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1569-1993

Publisher:

Elsevier

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

30 Aug 2021 19:05

Last Modified:

07 Sep 2021 07:57

Publisher DOI:

10.1016/j.jcf.2021.04.006

PubMed ID:

34088612

Uncontrolled Keywords:

Cohort study Cystic fibrosis Healthy controls Infancy Respiratory symptoms

BORIS DOI:

10.48350/159015

URI:

https://boris.unibe.ch/id/eprint/159015

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