Update on Histological Reporting Changes in Neuroendocrine Neoplasms.

Bräutigam, Konstantin; Rodríguez-Calero, Antonio; Kim-Fuchs, Corina; Kollár, Attila; Trepp, Roman; Marinoni, Ilaria; Perren, Aurel (2021). Update on Histological Reporting Changes in Neuroendocrine Neoplasms. Current Oncology Reports, 23(6), p. 65. Springer 10.1007/s11912-021-01062-6

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PURPOSE OF REVIEW

Classification and nomenclature of neuroendocrine neoplasms (NEN) have frequently changed over the last years. These changes reflect both increasing knowledge and international standardisation.

RECENT FINDINGS

The most recent changes in the Gastro-Entero-Pancreatic system induced the concept of well-differentiated NET with high proliferation rate (NET G3), explaining partially the heterogeneity of G3 NEN. Even if the nomenclature in pulmonary NEN is still different, the terms 'carcinoid' and 'atypical carcinoid' are widely overlapping with NET G1 and NET G2. Molecular data shows an additional heterogeneity both in well-differentiated NET and poorly differentiated NEC. However, no studies are available demonstrating clinical usefulness yet. The heterogeneity of NEN regarding the organ of origin, differentiation and molecular subtypes make development of personalised therapy a challenge needing more international and interdisciplinary collaborations and clinical trials allowing stratification according to biological subgroups.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Bräutigam, Konstantin; Rodríguez Calero, José Antonio; Kim-Fuchs, Corina; Kollár, Attila; Trepp, Roman; Marinoni, Ilaria and Perren, Aurel

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1534-6269

Publisher:

Springer

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

28 Sep 2021 11:39

Last Modified:

03 Oct 2021 03:01

Publisher DOI:

10.1007/s11912-021-01062-6

PubMed ID:

33855635

Uncontrolled Keywords:

Classification NEN NET Neuroendocrine tumour Pathology Reporting

BORIS DOI:

10.48350/159240

URI:

https://boris.unibe.ch/id/eprint/159240

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