Jaramillo, Valeria; Jendoubi, Jasmine; Maric, Angelina; Mensen, Armand; Heyse, Natalie C; Eberhard-Moscicka, Aleksandra K.; Wiest, Roland; Bassetti, Claudio L. A.; Huber, Reto (2021). Thalamic influence on slow wave slope renormalization during sleep. Annals of neurology, 90(5), pp. 821-833. Wiley-Blackwell 10.1002/ana.26217
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OBJECTIVE
Slow waves are thought to mediate an overall reduction in synaptic strength during sleep. The specific contribution of the thalamus to this so-called synaptic renormalization is unknown. Thalamic stroke is associated with daytime sleepiness, along with changes to sleep electroencephalography and cognition making it a unique "experiment of nature" to assess the relationship between sleep rhythms, synaptic renormalization, and daytime functions.
METHODS
Sleep was studied by polysomnography and high-density electroencephalography over 17 nights in patients with thalamic (n = 12) and 15 nights in patients with extra-thalamic (n = 11) stroke. Sleep electroencephalography overnight slow wave slope changes, and their relationship with subjective daytime sleepiness, cognition, and other functional tests were assessed.
RESULTS
Thalamic and extra-thalamic patients did not differ in terms of age, sleep duration or apnea-hypopnea index. Conversely, overnight slope changes were reduced in a large cluster of electrodes in thalamic compared to extra-thalamic stroke patients. This reduction was related to increased daytime sleepiness. No significant differences were found in other functional tests between the two groups.
INTERPRETATION
In patients with thalamic stroke a reduction in overnight slow wave slope change and increased daytime sleepiness was found. Sleep- and wake-centered mechanisms for this relationship are discussed. Overall, this study suggests a central role of the thalamus in synaptic renormalization. This article is protected by copyright. All rights reserved.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology |
UniBE Contributor: |
Jendoubi, Jasmine Léa, Mensen, Armand, Eberhard-Moscicka, Aleksandra Katarzyna, Wiest, Roland Gerhard Rudi, Bassetti, Claudio L.A. |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1531-8249 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Martin Zbinden |
Date Deposited: |
01 Oct 2021 15:15 |
Last Modified: |
25 Jul 2023 14:31 |
Publisher DOI: |
10.1002/ana.26217 |
PubMed ID: |
34516002 |
Additional Information: |
Claudio L. A. Bassetti and Reto Huber contributed equally to this work. |
Uncontrolled Keywords: |
High-density Electroencephalography (EEG) Restorative Function of Sleep Thalamic Stroke |
BORIS DOI: |
10.48350/159384 |
URI: |
https://boris.unibe.ch/id/eprint/159384 |
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