Vancura, Adrienne; Lanzós, Andrés; Bosch-Guiteras, Núria; Esteban, Mònica Torres; Gutierrez, Alejandro H; Haefliger, Simon; Johnson, Rory (2021). Cancer LncRNA Census 2 (CLC2): an enhanced resource reveals clinical features of cancer lncRNAs. NAR cancer, 3(2), zcab013. Oxford University Press 10.1093/narcan/zcab013
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Long non-coding RNAs (lncRNAs) play key roles in cancer and are at the vanguard of precision therapeutic development. These efforts depend on large and high-confidence collections of cancer lncRNAs. Here, we present the Cancer LncRNA Census 2 (CLC2). With 492 cancer lncRNAs, CLC2 is 4-fold greater in size than its predecessor, without compromising on strict criteria of confident functional/genetic roles and inclusion in the GENCODE annotation scheme. This increase was enabled by leveraging high-throughput transposon insertional mutagenesis screening data, yielding 92 novel cancer lncRNAs. CLC2 makes a valuable addition to existing collections: it is amongst the largest, contains numerous unique genes (not found in other databases) and carries functional labels (oncogene/tumour suppressor). Analysis of this dataset reveals that cancer lncRNAs are impacted by germline variants, somatic mutations and changes in expression consistent with inferred disease functions. Furthermore, we show how clinical/genomic features can be used to vet prospective gene sets from high-throughput sources. The combination of size and quality makes CLC2 a foundation for precision medicine, demonstrating cancer lncRNAs' evolutionary and clinical significance.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Vancura, Adrienne Nina, Lanzos Camaioni, Andrés Arturo, Häfliger, Simon, Johnson, Rory Baldwin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2632-8674 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Rebeka Gerber |
Date Deposited: |
06 Oct 2021 10:06 |
Last Modified: |
02 Mar 2023 23:35 |
Publisher DOI: |
10.1093/narcan/zcab013 |
PubMed ID: |
34316704 |
BORIS DOI: |
10.48350/159403 |
URI: |
https://boris.unibe.ch/id/eprint/159403 |
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