Klionsky, Daniel J; Petroni, Giulia; Amaravadi, Ravi K; Baehrecke, Eric H; Ballabio, Andrea; Boya, Patricia; Bravo-San Pedro, José Manuel; Cadwell, Ken; Cecconi, Francesco; Choi, Augustine M K; Choi, Mary E; Chu, Charleen T; Codogno, Patrice; Colombo, Maria Isabel; Cuervo, Ana Maria; Deretic, Vojo; Dikic, Ivan; Elazar, Zvulun; Eskelinen, Eeva-Liisa; Fimia, Gian Maria; ... (2021). Autophagy in major human diseases. The EMBO journal, 40(19), e108863. EMBO Press 10.15252/embj.2021108863
|
Text
Simon_Autophaagy_in_major_human_diseases.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (2MB) | Preview |
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
UniBE Contributor: |
Simon, Hans-Uwe |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1460-2075 |
Publisher: |
EMBO Press |
Language: |
English |
Submitter: |
Celine Joray |
Date Deposited: |
18 Jan 2022 15:29 |
Last Modified: |
22 Jan 2024 16:46 |
Publisher DOI: |
10.15252/embj.2021108863 |
PubMed ID: |
34459017 |
Uncontrolled Keywords: |
aging cancer inflammation metabolic syndromes neurodegeneration |
BORIS DOI: |
10.48350/160024 |
URI: |
https://boris.unibe.ch/id/eprint/160024 |
Actions (login required)
 |
Edit item |