Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests.

Masoodi, Mojgan; Gastaldelli, Amalia; Hyötyläinen, Tuulia; Arretxe, Enara; Alonso, Cristina; Gaggini, Melania; Brosnan, Julia; Anstee, Quentin M; Millet, Oscar; Ortiz, Pablo; Mato, Jose M; Dufour, Jean-François; Orešič, Matej (2021). Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests. Nature reviews, 18(12), pp. 835-856. Springer Nature 10.1038/s41575-021-00502-9

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Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide and is often associated with aspects of metabolic syndrome. Despite its prevalence and the importance of early diagnosis, there is a lack of robustly validated biomarkers for diagnosis, prognosis and monitoring of disease progression in response to a given treatment. In this Review, we provide an overview of the contribution of metabolomics and lipidomics in clinical studies to identify biomarkers associated with NAFLD and nonalcoholic steatohepatitis (NASH). In addition, we highlight the key metabolic pathways in NAFLD and NASH that have been identified by metabolomics and lipidomics approaches and could potentially be used as biomarkers for non-invasive diagnostic tests. Overall, the studies demonstrated alterations in amino acid metabolism and several aspects of lipid metabolism including circulating fatty acids, triglycerides, phospholipids and bile acids. Although we report several studies that identified potential biomarkers, few have been validated.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

Masoodi, Mojgan, Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1759-5053

Publisher:

Springer Nature

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

27 Oct 2021 08:08

Last Modified:

05 Dec 2022 15:53

Publisher DOI:

10.1038/s41575-021-00502-9

PubMed ID:

34508238

BORIS DOI:

10.48350/160183

URI:

https://boris.unibe.ch/id/eprint/160183

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