Targeting sialylation to treat central nervous system diseases.

Lünemann, Jan D; von Gunten, Stephan; Neumann, Harald (2021). Targeting sialylation to treat central nervous system diseases. Trends in Pharmacological Sciences, 42(12), pp. 998-1008. Elsevier 10.1016/j.tips.2021.09.002

[img] Text
von_Gunten_Targeting_sialylation_to_treat.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

Sialic acid-binding immunoglobulin-type lectins (SIGLECs) are membrane receptors that are preferentially expressed on immune cells and recognize sialylated proteins, lipids, and RNA. Sialic acids and signaling through SIGLECs are increasingly recognized for their essential roles in immune system homeostasis as well as nervous system development, plasticity, and repair. Dysregulated sialylation and SIGLEC dysfunctions contribute to several chronic diseases of the central nervous system (CNS) in which current therapeutic options are very limited. While only a few therapies targeting SIGLECs are currently being tested in clinical trials, the area emerged as one of the most dynamic and active fields in glycobiology and drug development. This review highlights recent insights into sialic acid and SIGLEC function in CNS pathologies and illustrates opportunities and challenges for the development of sialic acid-based and SIGLEC-targeted therapies for neurological diseases.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

von Gunten, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1873-3735

Publisher:

Elsevier

Language:

English

Submitter:

Celine Joray

Date Deposited:

19 Oct 2021 17:39

Last Modified:

14 Nov 2021 00:14

Publisher DOI:

10.1016/j.tips.2021.09.002

PubMed ID:

34607695

Uncontrolled Keywords:

Siglec drug discovery glycobiology neurology sialic acid therapy

BORIS DOI:

10.48350/160194

URI:

https://boris.unibe.ch/id/eprint/160194

Actions (login required)

Edit item Edit item
Provide Feedback