Capture, crawl, cross: the T cell code to breach the blood-brain barriers

Engelhardt, Britta; Ransohoff, Richard M (2012). Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends in immunology, 33(12), pp. 579-89. Oxford: Elsevier Current Trends 10.1016/j.it.2012.07.004

[img] Text
1-s2.0-S1471490612001263-main.pdf - Published Version
Restricted to registered users only

Download (1MB)

The central nervous system (CNS) is an immunologically privileged site to which access of circulating immune cells is tightly controlled by the endothelial blood-brain barrier (BBB; see Glossary) localized in CNS microvessels, and the epithelial blood-cerebrospinal fluid barrier (BCSFB) within the choroid plexus. As a result of the specialized structure of the CNS barriers, immune cell entry into the CNS parenchyma involves two differently regulated steps: migration of immune cells across the BBB or BCSFB into the cerebrospinal fluid (CSF)-drained spaces of the CNS, followed by progression across the glia limitans into the CNS parenchyma. With a focus on multiple sclerosis (MS) and its animal models, this review summarizes the distinct molecular mechanisms required for immune cell migration across the different CNS barriers.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Engelhardt, Britta

ISSN:

1471-4906

Publisher:

Elsevier Current Trends

Funders:

[4] Swiss National Science Foundation ; [7] Swiss Multiple Sclerosis Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:39

Last Modified:

05 Dec 2022 14:12

Publisher DOI:

10.1016/j.it.2012.07.004

PubMed ID:

22926201

Web of Science ID:

000312055700001

BORIS DOI:

10.7892/boris.16034

URI:

https://boris.unibe.ch/id/eprint/16034 (FactScience: 223584)

Actions (login required)

Edit item Edit item
Provide Feedback