Capture, crawl, cross: the T cell code to breach the blood-brain barriers

Engelhardt, Britta; Ransohoff, Richard M (2012). Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends in immunology, 33(12), pp. 579-89. Oxford: Elsevier Current Trends 10.1016/j.it.2012.07.004

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The central nervous system (CNS) is an immunologically privileged site to which access of circulating immune cells is tightly controlled by the endothelial blood-brain barrier (BBB; see Glossary) localized in CNS microvessels, and the epithelial blood-cerebrospinal fluid barrier (BCSFB) within the choroid plexus. As a result of the specialized structure of the CNS barriers, immune cell entry into the CNS parenchyma involves two differently regulated steps: migration of immune cells across the BBB or BCSFB into the cerebrospinal fluid (CSF)-drained spaces of the CNS, followed by progression across the glia limitans into the CNS parenchyma. With a focus on multiple sclerosis (MS) and its animal models, this review summarizes the distinct molecular mechanisms required for immune cell migration across the different CNS barriers.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute

UniBE Contributor:

Engelhardt, Britta

ISSN:

1471-4906

Publisher:

Elsevier Current Trends

Funders:

[4] Swiss National Science Foundation
[7] Swiss Multiple Sclerosis Society

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:39

Last Modified:

29 Dec 2014 16:38

Publisher DOI:

10.1016/j.it.2012.07.004

PubMed ID:

22926201

Web of Science ID:

000312055700001

BORIS DOI:

10.7892/boris.16034

URI:

https://boris.unibe.ch/id/eprint/16034 (FactScience: 223584)

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