The anatomical and cellular basis of immune surveillance in the central nervous system

Ransohoff, Richard M; Engelhardt, Britta (2012). The anatomical and cellular basis of immune surveillance in the central nervous system. Nature reviews - immunology, 12(9), pp. 623-35. London: Nature Publishing Group 10.1038/nri3265

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The central nervous system (CNS) comprises the brain, spinal cord, optic nerves and retina, and contains post-mitotic, delicate cells. As the rigid coverings of the CNS render swelling dangerous and destructive, inflammatory reactions must be carefully controlled in CNS tissues. Nevertheless, effector immune responses that protect the host during CNS infection still occur in the CNS. Here, we describe the anatomical and cellular basis of immune surveillance in the CNS, and explain how this shapes the unique immunology of these tissues. The Review focuses principally on insights gained from the study of autoimmune responses in the CNS and to a lesser extent on models of infectious disease. Furthermore, we propose a new model to explain how antigen-specific T cell responses occur in the CNS.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Theodor Kocher Institute
UniBE Contributor:	Engelhardt, Britta
ISSN:	1474-1733
Publisher:	Nature Publishing Group
Funders:	[4] Swiss National Science Foundation ; [7] Swiss Multiple Sclerosis Society
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:39
Last Modified:	05 Dec 2022 14:12
Publisher DOI:	10.1038/nri3265
PubMed ID:	22903150
Web of Science ID:	000308248200010
URI:	https://boris.unibe.ch/id/eprint/16035 (FactScience: 223585)