Aswendt, Markus; Green, Claudia; Sadler, Rebecca; Llovera, Gemma; Dzikowski, Lauren; Heindl, Steffanie; Gomez de Agüero, Mercedes; Diedenhofen, Michael; Vogel, Stefanie; Wieters, Frederique; Wiedermann, Dirk; Liesz, Arthur; Hoehn, Mathias (2021). The gut microbiota modulates brain network connectivity under physiological conditions and after acute brain ischemia. iScience, 24(10), p. 103095. Elsevier 10.1016/j.isci.2021.103095
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The gut microbiome has been implicated as a key regulator of brain function in health and disease. But the impact of gut microbiota on functional brain connectivity is unknown. We used resting-state functional magnetic resonance imaging in germ-free and normally colonized mice under naive conditions and after ischemic stroke. We observed a strong, brain-wide increase of functional connectivity in germ-free animals. Graph theoretical analysis revealed significant higher values in germ-free animals, indicating a stronger and denser global network but with less structural organization. Breakdown of network function after stroke equally affected germ-free and colonized mice. Results from histological analyses showed changes in dendritic spine densities, as well as an immature microglial phenotype, indicating impaired microglia-neuron interaction in germ-free mice as potential cause of this phenomenon. These results demonstrate the substantial impact of bacterial colonization on brain-wide function and extend our so far mainly (sub) cellular understanding of the gut-brain axis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie |
UniBE Contributor: |
Gomez de Agüero Tamargo, Maria de la Mercedes |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2589-0042 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Rahel Fuhrer |
Date Deposited: |
08 Nov 2021 17:01 |
Last Modified: |
29 Apr 2024 23:08 |
Publisher DOI: |
10.1016/j.isci.2021.103095 |
PubMed ID: |
34622150 |
Uncontrolled Keywords: |
Neuroscience microbiome |
BORIS DOI: |
10.48350/160620 |
URI: |
https://boris.unibe.ch/id/eprint/160620 |
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