Kolev, Mirjam; Sarbu, Adela-Cristina; Walder, Anna; Moeller, Burkhard; Maurer, Britta; Kollert, Florian; Semmo, Nasser (9 September 2021). Belimumab in Autoimmune Liver Diseases with associated Sjögren’s Syndrome. Swiss medical weekly, 151(S253), p. 25. EMH Media
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Kolev_Mirjam_Abstract_151_smw_suppl_253.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (9MB) | Preview |
Background: B cell-activating factor (BAFF) levels are elevated in autoimmune
hepatitis (AIH) and primary biliary cholangitis (PBC). About 20%
of patients with PBC and 5% with AIH have a Sjögren’s syndrome (SjS).
PBC and SjS have many features in common. Belimumab (anti-BAFF)
shows positive effects in SjS.
Methods: Retrospective analysis on treatment response to belimumab
in three female patients with AIH and/or PBC with SjS. Patient 1: 52y,
with AIH (F2), PBC and SjS. Indication: active AIH with intolerance to
standard treatment; belimumab since 01/20. Patient 2: 72y, with PBC
(F3) and SjS. Indication: refractory PBC; belimumab since 11/20. Patient
3: 54y, with PBC (F2, ductopenia), SjS and erosive rheumatoid arthritis.
Indication: refractory PBC; belimumab since 11/20.
Results: Patient 1: AIH in remission under belimumab monotherapy. Patient
2: PBC in remission 6 months after treatment start. Patient 3: Cholestasis
stable. Slight decrease of mildly elevated transaminases and almost
normalization of IgM. The effects on SjS were overall encouraging
in all patients.
Conclusions: These preliminary findings indicate belimumab as a promising
treatment option in AIH and PBC, with so far no safety concerns.
Our study shows how the occurrence of different autoimmune diseases
can guide us to further personalize treatment and highlights the
strengths of a tight collaboration between hepatology and rheumatology
Item Type: |
Conference or Workshop Item (Abstract) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine |
UniBE Contributor: |
Kolev, Mirjam, Sarbu, Adela-Cristina, Walder, Anna, Möller, Burkhard, Maurer, Britta, Kollert, Florian Kim, Semmo, Nasser |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1424-3997 |
Publisher: |
EMH Media |
Language: |
English |
Submitter: |
Rahel Fuhrer |
Date Deposited: |
09 Nov 2021 14:23 |
Last Modified: |
05 Dec 2022 15:54 |
Additional Information: |
H9 |
BORIS DOI: |
10.48350/160803 |
URI: |
https://boris.unibe.ch/id/eprint/160803 |
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