Neuronal current imaging: An experimental method to investigate electrical currents in dogs with idiopathic epilepsy.

Unger, Daniela; Wiest, Roland; Kiefer, Claus; Raillard, Mathieu; Dutil, Guillaume F.; Stein, Veronika M.; Schweizer, Daniela (2021). Neuronal current imaging: An experimental method to investigate electrical currents in dogs with idiopathic epilepsy. Journal of veterinary internal medicine, 35(6), pp. 2828-2836. Wiley-Blackwell 10.1111/jvim.16270

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BACKGROUND

The diagnosis of idiopathic epilepsy (IE) in dogs is based on exclusion of other potential causes of seizures. Recently, a novel magnetic resonance imaging (MRI) sequence that utilizes a variant of the rotary saturation approach has been suggested to detect weak transient magnetic field oscillations generated by neuronal currents in humans with epilepsy.

HYPOTHESIS/OBJECTIVES

Effects on the magnetic field evoked by intrinsic epileptic activity can be detected by MRI in the canine brain. As proof-of-concept, the novel MRI sequence to detect neuronal currents was applied in dogs.

ANIMALS

Twelve dogs with IE and 5 control dogs without a history of epileptic seizures were examined.

METHODS

Prospective case-control study as proof-of-concept. All dogs underwent a clinical neurological examination, scalp electroencephalography, cerebrospinal fluid analysis, and MRI. The MRI examination included a spin-locking (SL) experiment applying a low-power on-resonance radiofrequency pulse in a predefined frequency domain in the range of oscillations generated by the epileptogenic tissue.

RESULTS

In 11 of 12 dogs with IE, rotary saturation effects were detected by the MRI sequence. Four of 5 control dogs did not show rotary saturation effects. One control dog with a diagnosis of neuronal ceroid lipofuscinosis had SL-related effects, but did not have epileptic seizures clinically.

CONCLUSIONS AND CLINICAL IMPORTANCE

The proposed MRI method detected neuronal currents in dogs with epileptic seizures and represents a potential new line of research to investigate neuronal currents possibly related to IE in dogs.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Unger, Daniela Maria; Wiest, Roland; Kiefer, Claus; Raillard, Mathieu Clément; Dutil, Guillaume Fabien; Stein, Veronika Maria and Schweizer, Daniela Esther

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0891-6640

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Martin Zbinden

Date Deposited:

18 Nov 2021 09:23

Last Modified:

24 Dec 2021 00:13

Publisher DOI:

10.1111/jvim.16270

PubMed ID:

34623697

Uncontrolled Keywords:

MRI NCI dog pcSIRS seizure veterinary

BORIS DOI:

10.48350/160837

URI:

https://boris.unibe.ch/id/eprint/160837

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