Diagnostic use of fine-needle aspiration cytology and core-needle biopsy in head and neck sarcomas.

Sheppard, Sean C.; Borner, Urs; Wartenberg, Martin; Giger, Roland; Nisa Hernández, Lluís (2021). Diagnostic use of fine-needle aspiration cytology and core-needle biopsy in head and neck sarcomas. Head & neck, 43(6), pp. 1939-1948. Wiley 10.1002/hed.26670

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The diagnostic role of fine-needle aspiration cytology (FNAC) and core-needle biopsy (CNB) has not been comprehensively assessed in head and neck sarcomas. A systematic review of published cases (1990-2020) was conducted. Diagnostic performance of both FNAC/CNB to determine tumor dignity and histopathological diagnosis was calculated. One hundred and sixty-eight cases were included for which FNAC (n = 156), CNB (n = 8), or both (n = 4) were used. Predominant histologies were skeletal muscle, chondrogenic and vascular sarcomas. FNAC correctly assessed dignity in 76.3% and histology in 45% of cases. Dignity was significantly better for vascular tumors, metastatic and recurrent specimens, and worse for chondrogenic sarcomas. CNB showed a 92% accuracy to identify dignity and 83% for histopathology. FNAC and CNB are useful methods for the diagnosis of head and neck sarcomas, particularly well-suited in the context of recurrent or metastatic disease. The role of CNB remains largely unexplored for this indication.

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