Phylobioactive hotspots in plant resources used to treat Chagas disease.

Salm, Andrea; Krishnan, Sandhya R.; Collu, Marta; Danton, Ombeline; Hamburger, Matthias; Leonti, Marco; Almanza, Giovanna; Gertsch, Jürg (2021). Phylobioactive hotspots in plant resources used to treat Chagas disease. iScience, 24(4), p. 102310. Elsevier 10.1016/j.isci.2021.102310

[img]
Preview
Text
main.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (5MB) | Preview

Globally, more than six million people are infected with Trypanosoma cruzi, the causative protozoan parasite of the vector-borne Chagas disease (CD). We conducted a cross-sectional ethnopharmacological field study in Bolivia among different ethnic groups where CD is hyperendemic. A total of 775 extracts of botanical drugs used in Bolivia in the context of CD and botanical drugs from unrelated indications from the Mediterranean De Materia Medica compiled by Dioscorides two thousand years ago were profiled in a multidimensional assay uncovering different antichagasic natural product classes. Intriguingly, the phylobioactive anthraquinone hotspot matched the antichagasic activity of Senna chloroclada, the taxon with the strongest ethnomedical consensus for treating CD among the Izoceño-Guaraní. Testing common 9,10-anthracenedione derivatives in T. cruzi cellular infection assays demarcates hydroxyanthraquinone as a potential antichagasic lead scaffold. Our study systematically uncovers in vitro antichagasic phylogenetic hotspots in the plant kingdom as a potential resource for drug discovery based on ethnopharmacological hypotheses.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Salm, Andrea Alejandra; Radha Krishnan, Sandhya Krishnan and Gertsch, Jürg

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2589-0042

Publisher:

Elsevier

Language:

English

Submitter:

Barbara Franziska Järmann-Bangerter

Date Deposited:

02 Dec 2021 09:13

Last Modified:

05 Dec 2021 01:46

Publisher DOI:

10.1016/j.isci.2021.102310

PubMed ID:

33870129

Uncontrolled Keywords:

Bioactive Plant Product Biological Sciences Ethnobotany Ethnopharmacology Natural Product Chemistry Plant Biology Plants

BORIS DOI:

10.48350/161547

URI:

https://boris.unibe.ch/id/eprint/161547

Actions (login required)

Edit item Edit item
Provide Feedback