Outcome of patients with mantle cell lymphoma after autologous stem cell transplantation in the pre-CAR T-cell era Letter.

Mathys, Anina; Bacher, Ulrike; Banz, Yara; Legros, Myriam; Mansouri Taleghani, Behrouz; Novak, Urban; Pabst, Thomas (2021). Outcome of patients with mantle cell lymphoma after autologous stem cell transplantation in the pre-CAR T-cell era Letter. (In Press). Hematological oncology Wiley 10.1002/hon.2952

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INTRODUCTION

Mantle cell lymphoma (MCL) patients can be treated with intensive induction therapy, followed by high dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) for consolidation and subsequent anti-CD20 maintenance. For patients relapsing after bruton tyrosine kinase (BTK) inhibitors, CAR T-cell therapy became available in late 2020 fueling the interest in outcomes of relapsing MCL patients.

METHODS

We retrospectively analyzed the outcome of MCL patients receiving HDCT/ASCT at our center between 2000 and 2021, thus, before availability of CAR-T cells.

RESULTS

We identified 97 MCL patients undergoing HDCT/ASCT in this period with a median follow-up of 52 months. 43 (44%) patients ultimately relapsed, and 29 (30%) have died. The median progression-free survival (PFS) for the entire cohort was 48 months and overall survival (OS) was 202 months. Relapsing patients had a median PFS of only 28 months and median OS of 105 months. The OS of relapsing patients receiving BTK inhibitors was 148 versus 78 months in patients who never received BTK inhibitors (p=0.1175).

CONCLUSION

Even after HDCT/ASCT, a substantial proportion of MCL patients will relapse and ultimately die of the disease, emphasizing the need for new therapeutic options including CAR T-cell treatment for this lymphoma subtype. This article is protected by copyright. All rights reserved.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Bacher, Vera Ulrike; Banz Wälti, Yara; Legros, Myriam; Mansouri Taleghani, Behrouz; Novak, Urban and Pabst, Thomas Niklaus

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1099-1069

Publisher:

Wiley

Language:

English

Submitter:

Pierrette Durand Lüthi

Date Deposited:

26 Nov 2021 17:24

Last Modified:

26 Nov 2021 17:24

Publisher DOI:

10.1002/hon.2952

PubMed ID:

34817087

Uncontrolled Keywords:

CAR T-cell Mantle cell lymphoma (MCL) autologous stem cell transplantation (ASCT) lymphoma outcome

BORIS DOI:

10.48350/161613

URI:

https://boris.unibe.ch/id/eprint/161613

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