Sparchez, Zeno; Radu, Pompilia; Bartos, Adrian; Nenu, Iuliana; Craciun, Rares; Mocan, Tudor; Horhat, Adelina; Spârchez, Mihaela; Dufour, Jean-François (2021). Combined treatments in hepatocellular carcinoma: Time to put them in the guidelines? World journal of gastrointestinal oncology, 13(12), pp. 1896-1918. Baishideng Publishing Group 10.4251/wjgo.v13.i12.1896
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The time for battling cancer has never been more suitable than nowadays and fortunately against hepatocellular carcinoma (HCC) we do have a far-reaching arsenal. Moreover, because liver cancer comprises a plethora of stages-from very early to advanced disease and with many treatment options–from surgery to immunotherapy trials–it leaves the clinician a wide range of options. The scope of our review is to throw light on combination treatments that seem to be beyond guidelines and to highlight these using evidence-based analysis of the most frequently used combination therapies, discussing their advantages and flaws in comparison to the current standard of care. One particular combination therapy seems to be in the forefront: Transarterial chemoembolization plus ablation for medium-size non-resectable HCC (3-5 cm), which is currently at the frontier between Barcelona Clinic Liver Cancer classification A and B. Not only does it improve the outcome in contrast to each individual therapy, but it also seems to have similar results to surgery. Also, the abundance of immune checkpoint inhibitors that have appeared lately in clinical trials are bringing promising results against HCC. Although the path of combination therapies in HCC is still filled with uncertainty and caveats, in the following years the hepatology and oncology fields could witness an HCC guideline revolution.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology |
UniBE Contributor: |
Radu, Pompilia, Dufour, Jean-François |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1948-5204 |
Publisher: |
Baishideng Publishing Group |
Language: |
English |
Submitter: |
Rahel Fuhrer |
Date Deposited: |
11 Jan 2022 08:28 |
Last Modified: |
05 Dec 2022 15:57 |
Publisher DOI: |
10.4251/wjgo.v13.i12.1896 |
BORIS DOI: |
10.48350/162528 |
URI: |
https://boris.unibe.ch/id/eprint/162528 |
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