Wu, Linghe; Baylan, Umit; van der Leeden, Britt; Schurink, Bernadette; Roos, Eva; Schalkwijk, Casper G; Bugiani, Marianna; van der Valk, Paul; van Rossum, Albert C; Zeerleder, Sacha S.; Heunks, Leo M A; Boon, Reinier A; de Boer, Onno J; van der Wal, Allard C; Niessen, Hans W M; Krijnen, Paul A J (2022). Cardiac inflammation and microvascular procoagulant changes are decreased in second wave compared to first wave deceased COVID-19 patients. International journal of cardiology, 349, pp. 157-165. Elsevier 10.1016/j.ijcard.2021.11.079
|
Text
1-s2.0-S0167527321019707-main.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (3MB) | Preview |
BACKGROUND
Compelling evidence has shown cardiac involvement in COVID-19 patients. However, the overall majority of these studies use data obtained during the first wave of the pandemic, while recently differences have been reported in disease course and mortality between first- and second wave COVID-19 patients. The aim of this study was to analyze and compare cardiac pathology between first- and second wave COVID-19 patients.
METHODS
Autopsied hearts from first- (n = 15) and second wave (n = 10) COVID-19 patients and from 18 non-COVID-19 control patients were (immuno)histochemically analyzed. CD45+ leukocyte, CD68+ macrophage and CD3+ T lymphocyte infiltration, cardiomyocyte necrosis and microvascular thrombosis were quantified. In addition, the procoagulant factors Tissue Factor (TF), Factor VII (FVII), Factor XII (FXII), the anticoagulant protein Dipeptidyl Peptidase 4 (DPP4) and the advanced glycation end-product N(ε)-Carboxymethyllysine (CML), as markers of microvascular thrombogenicity and dysfunction, were quantified.
RESULTS
Cardiac inflammation was significantly decreased in second wave compared to first wave COVID-19 patients, predominantly related to a decrease in infiltrated lymphocytes and the occurrence of lymphocytic myocarditis. This was accompanied by significant decreases in cardiomyocyte injury and microvascular thrombosis. Moreover, microvascular deposits of FVII and CML were significantly lower in second wave compared to first wave COVID-19 patients.
CONCLUSIONS
These results show that in our cohort of fatal COVID-19 cases cardiac inflammation, cardiomyocyte injury and microvascular thrombogenicity were markedly decreased in second wave compared to first wave patients. This may reflect advances in COVID-19 treatment related to an increased use of steroids in the second COVID-19 wave.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Hämatologie (Erwachsene) |
UniBE Contributor: |
Zeerleder, Sacha Sergio |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0167-5273 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pierrette Durand Lüthi |
Date Deposited: |
10 Jan 2022 10:06 |
Last Modified: |
05 Dec 2022 15:57 |
Publisher DOI: |
10.1016/j.ijcard.2021.11.079 |
PubMed ID: |
34871622 |
Uncontrolled Keywords: |
COVID-19 First and second wave Heart Inflammation Thrombosis microvasculature |
BORIS DOI: |
10.48350/162617 |
URI: |
https://boris.unibe.ch/id/eprint/162617 |
Actions (login required)
 |
Edit item |