Thormann, Wolfgang; Mosher, Richard A (2022). Dynamic computer simulations of electrophoresis: 2010-2020. Electrophoresis, 43(1-2), pp. 10-36. Wiley 10.1002/elps.202100191
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The transport of components in liquid media under the influence of an applied electric field can be described with the continuity equation. It represents a nonlinear conservation law that is based upon the balance laws of continuous transport processes and can be solved in time and space numerically. This procedure is referred to as dynamic computer simulation. Since its inception four decades ago, the state of dynamic computer simulation software and its use has progressed significantly. Dynamic models are the most versatile tools to explore the fundamentals of electrokinetic separations and provide insights into the behavior of buffer systems and sample components of all electrophoretic separation methods, including moving boundary electrophoresis, CZE, CGE, ITP, IEF, EKC, ACE, and CEC. This article is a continuation of previous reviews (Electrophoresis 2009, 30, S16-S26 and Electrophoresis 2010, 31, 726-754) and summarizes the progress and achievements made during the 2010 to 2020 time period in which some of the existing dynamic simulators were extended and new simulation packages were developed. This review presents the basics and extensions of the three most used one-dimensional simulators, provides a survey of new one-dimensional simulators, outlines an overview of multi-dimensional models, and mentions models that were briefly reported in the literature. A comprehensive discussion of simulation applications and achievements of the 2010 to 2020 time period is also included.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases |
UniBE Contributor: |
Thormann, Wolfgang |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1522-2683 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Wolfgang Thormann |
Date Deposited: |
05 Jan 2022 16:17 |
Last Modified: |
24 Jun 2023 16:30 |
Publisher DOI: |
10.1002/elps.202100191 |
PubMed ID: |
34287996 |
Uncontrolled Keywords: |
Computer simulation Electrophoresis Isoelectric focusing Isotachophoresis Stacking |
BORIS DOI: |
10.48350/162970 |
URI: |
https://boris.unibe.ch/id/eprint/162970 |
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