Granulocyte Colony-stimulating Factor Producing Oropharyngeal Squamous Cell Carcinoma.

Schurmann, Gregory; Zweifel, Martin; Giger, Roland; Rau, Tilman T; Vinzens, Sarah; Dettmer, Matthias S; Kurian, Yojena (2021). Granulocyte Colony-stimulating Factor Producing Oropharyngeal Squamous Cell Carcinoma. In Vivo, 35(3), pp. 1785-1790. International Institute of Anticancer Research (IIAR) 10.21873/invivo.12438

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CASE REPORT

We report on the case of a 47-year old woman with granulocyte colony-stimulating factor (G-CSF)-producing relapsed oropharyngeal squamous cell cancer. Palliative immunotherapy with nivolumab was started. Absolute neutrophilic count increased during the course of immunotherapy and correlated with tumour progression. Under chemotherapy with weekly paclitaxel, dramatic tumour regression and decreasing absolute neutrophilic count were noted. G-CSF concentration in serum increased from 4.77 to 9.61 pg/ml during the final phase of tumour progression. Immunohistochemical staining of the initial biopsies showed that some of the tumour cells as well as infiltrating cells stained positively for G-CSF, and some of the tumour cells even stained positively for the G-CSF receptor.

CONCLUSION

Leukaemoid reaction in malignant disease with increased neutrophilic granulocytes has been shown to correlate with dismal prognosis in other tumours. The role of G-CSF in progression and prognosis of head and neck squamous cell carcinomas is still unclear but in patients with these tumours there seems also to be a correlation between elevated G-CSF and poor prognosis. Further systematic evaluation of G-CSF secretion in this tumour entity should clarify the role and potential treatment possibilities for these tumours.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)

UniBE Contributor:

Giger, Roland; Rau, Tilman and Dettmer, Matthias

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0258-851X

Publisher:

International Institute of Anticancer Research (IIAR)

Language:

English

Submitter:

Stefan Weder

Date Deposited:

25 Jan 2022 09:59

Last Modified:

25 Jan 2022 10:06

Publisher DOI:

10.21873/invivo.12438

PubMed ID:

33910863

Uncontrolled Keywords:

Oropharyngeal carcinoma granulocyte colony-stimulating factor immunotherapy leukocytosis neutrophilic granulocyte paraneoplastic syndrome

BORIS DOI:

10.48350/163538

URI:

https://boris.unibe.ch/id/eprint/163538

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