The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology.

Hugonnet, Marjolaine; Singh, Pushpita; Haas, Quentin; von Gunten, Stephan (2021). The Distinct Roles of Sialyltransferases in Cancer Biology and Onco-Immunology. Frontiers in immunology, 12, p. 799861. Frontiers Research Foundation 10.3389/fimmu.2021.799861

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Aberrant glycosylation is a key feature of malignant transformation. Hypersialylation, the enhanced expression of sialic acid-terminated glycoconjugates on the cell surface, has been linked to immune evasion and metastatic spread, eventually by interaction with sialoglycan-binding lectins, including Siglecs and selectins. The biosynthesis of tumor-associated sialoglycans involves sialyltransferases, which are differentially expressed in cancer cells. In this review article, we provide an overview of the twenty human sialyltransferases and their roles in cancer biology and immunity. A better understanding of the individual contribution of select sialyltransferases to the tumor sialome may lead to more personalized strategies for the treatment of cancer.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Faculty Institutions > Bern Center for Precision Medicine (BCPM)

UniBE Contributor:

Hugonnet, Marjolaine Claire; Singh, Pushpita; Haas, Quentin and von Gunten, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Celine Joray

Date Deposited:

19 Jan 2022 11:40

Last Modified:

23 Jan 2022 01:52

Publisher DOI:

10.3389/fimmu.2021.799861

PubMed ID:

34975914

Uncontrolled Keywords:

cancer sialic acid sialyltransferases tumor glycosylation tumor immunology

BORIS DOI:

10.48350/164343

URI:

https://boris.unibe.ch/id/eprint/164343

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