Bick, Alexander G; Popadin, Konstantin; Thorball, Christian W; Uddin, Md Mesbah; Zanni, Markella V; Yu, Bing; Cavassini, Matthias; Rauch, Andri; Tarr, Philip; Schmid, Patrick; Bernasconi, Enos; Günthard, Huldrych F; Libby, Peter; Boerwinkle, Eric; McLaren, Paul J; Ballantyne, Christie M; Grinspoon, Steven; Natarajan, Pradeep; Fellay, Jacques (2022). Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV. Scientific reports, 12(1), p. 577. Springer Nature 10.1038/s41598-021-04308-2
|
Text
41598_2021_Article_4308.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
People living with human immunodeficiency virus (PLWH) have significantly increased risk for cardiovascular disease in part due to inflammation and immune dysregulation. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition and expansion of hematopoietic stem cells due to leukemogenic driver mutations, increases risk for both hematologic malignancy and coronary artery disease (CAD). Since increased inflammation is hypothesized to be both a cause and consequence of CHIP, we hypothesized that PLWH have a greater prevalence of CHIP. We searched for CHIP in multi-ethnic cases from the Swiss HIV Cohort Study (SHCS, n = 600) and controls from the Atherosclerosis Risk in the Communities study (ARIC, n = 8111) from blood DNA-derived exome sequences. We observed that HIV is associated with a twofold increase in CHIP prevalence, both in the whole study population and in a subset of 230 cases and 1002 matched controls selected by propensity matching to control for demographic imbalances (SHCS 7%, ARIC 3%, p = 0.005). We also observed that ASXL1 is the most commonly mutated CHIP-associated gene in PLWH. Our results suggest that CHIP may contribute to the excess cardiovascular risk observed in PLWH.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Rauch, Andri |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Annelies Luginbühl |
Date Deposited: |
22 Feb 2022 10:57 |
Last Modified: |
05 Dec 2022 16:04 |
Publisher DOI: |
10.1038/s41598-021-04308-2 |
PubMed ID: |
35022435 |
BORIS DOI: |
10.48350/164529 |
URI: |
https://boris.unibe.ch/id/eprint/164529 |
Actions (login required)
 |
Edit item |