Auditory spatial cueing reduces neglect after right-hemispheric stroke: a proof of concept study

Kaufmann, B.C.; Cazzoli, D.; Bartolomeo, P.; Frey, J.; Pflugshaupt, T.; Knobel, S.E.J.; Nef, T.; Müri, R.M.; Nyffeler, T. (2022). Auditory spatial cueing reduces neglect after right-hemispheric stroke: a proof of concept study. Cortex, 148, pp. 152-167. Elsevier 10.1016/j.cortex.2021.12.009

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Spatial neglect after right-hemispheric stroke, characterized by the failure to attend or respond to the contralesional space, is a strong negative outcome predictor. Neglect is a supramodal syn-drome affecting not only the visual but also the auditory modality. Preliminary studies used this audio-visual cross-modal effect to show short-lasting effects on attention towards the neglected space. The aim of the present study was to introduce a new technique of auditory stimulation combining the unspecific effect of music (i.e. patients choose their preferred music) with the effects of auditory spatial cueing (i.e. the music is presented dynamically as moving from right to left). The effect of this new auditory stimulation technique was investigated in two proof-of-concept experiments using repeated-measures, cross-over designs including overall 21 patients with visual neglect after a first right-hemispheric stroke. In experiment I (n=9), neglect patients showed a significantly larger improvement in Letter Cancellation after listening to preferred music with than without auditory spatial cueing. After granting the feasibility of this new auditory stimulation technique, we investigated the long-term aftereffects in experiment II (n=12). Herefore, we used video-oculography during Free Visual Exploration, a sensitive and reliable tool to assess spatial attention over time. Listening to music with auditory spatial cueing – as compared to music without auditory spatial cueing – significantly improved neglect severity in terms of visual exploration behaviour for up to 3h. A voxel-based-lesion-symptom mapping analysis over all patients revealed that the response variability in listening to music with auditory spatial cueing is determined by the integrity of the right inferior parietal lobule, the second branch of the superior longitudinal fascicle, and parieto-parietal callosal fibres. Our study shows that listening to music with auditory spatial cueing significantly reduces neglect severity and has the potential to be used as an add-on in the neurorehabilitation of neglect.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
07 Faculty of Human Sciences > Institute of Psychology
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Cazzoli, Dario, Knobel, Samuel Elia Johannes, Nef, Tobias, Müri, René Martin, Nyffeler, Thomas

Subjects:

600 Technology > 610 Medicine & health
100 Philosophy > 150 Psychology
500 Science > 570 Life sciences; biology
600 Technology > 620 Engineering

ISSN:

0010-9452

Publisher:

Elsevier

Language:

English

Submitter:

Aileen Charlotte Naef

Date Deposited:

22 Feb 2022 16:34

Last Modified:

05 Dec 2022 16:05

Publisher DOI:

10.1016/j.cortex.2021.12.009

PubMed ID:

35176552

BORIS DOI:

10.48350/164830

URI:

https://boris.unibe.ch/id/eprint/164830

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