Increased placental phospholipid levels in pre-eclamptic pregnancies

Huang, Xiao; Jain, Arjun; Baumann, Marc; Körner, Meike; Surbek, Daniel; Bütikofer, Peter; Albrecht, Christiane (2013). Increased placental phospholipid levels in pre-eclamptic pregnancies. International journal of molecular sciences, 14(2), pp. 3487-99. Basel: MDPI 10.3390/ijms14023487

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Physiological pregnancy is associated with an increase in lipids from the first to the third trimester. This is a highly regulated response to satisfy energy and membrane demands of the developing fetus. Pregnancy disorders, such as pre-eclampsia, are associated with a dysregulation of lipid metabolism manifesting in increased maternal plasma lipid levels. In fetal placental tissue, only scarce information on the lipid profile is available, and data for gestational diseases are lacking. In the present study, we investigated the placental lipid content in control versus pre-eclamptic samples, with the focus on tissue phospholipid levels and composition. We found an increase in total phospholipid content as well as changes in individual phospholipid classes in pre-eclamptic placental tissues compared to controls. These alterations could be a source of placental pathological changes in pre-eclampsia, such as lipid peroxide insult or dysregulation of lipid transport across the syncytiotrophoblast.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
UniBE Contributor:	Huang, Xiao, Jain, Arjun, Baumann, Marc, Surbek, Daniel, Bütikofer, Peter, Albrecht, Christiane
Subjects:	500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health
ISSN:	1661-6596
Publisher:	MDPI
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:40
Last Modified:	07 Aug 2024 15:45
Publisher DOI:	10.3390/ijms14023487
PubMed ID:	23389044
Web of Science ID:	000315397900070
URI:	https://boris.unibe.ch/id/eprint/16491 (FactScience: 224141)