Hanke, Julie M.; Schindler, Kaspar A; Seiler, Andrea (2022). On the relationships between epilepsy, sleep, and Alzheimer's disease: A narrative review. Epilepsy & behavior, 129, p. 108609. Elsevier 10.1016/j.yebeh.2022.108609
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Epilepsy, sleep, and Alzheimer's disease (AD) are tightly and potentially causally interconnected. The aim of our review was to investigate current research directions on these relationships. Our hope is that they may indicate preventive measures and new treatment options for early neurodegeneration. We included articles that assessed all three topics and were published during the last ten years. We found that this literature corroborates connections on various pathophysiological levels, including sleep-stage-related epileptiform activity in AD, the negative consequences of different sleep disorders on epilepsy and cognition, common biochemical pathways as well as network dysfunctions. Here we provide a detailed overview of these topics and we discuss promising diagnostic and therapeutic consequences.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Hanke, Julie Marie, Schindler, Kaspar Anton, Seiler, Andrea Barbara |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1525-5050 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Feb 2022 13:37 |
Last Modified: |
06 Jan 2023 23:22 |
Publisher DOI: |
10.1016/j.yebeh.2022.108609 |
PubMed ID: |
35176650 |
Uncontrolled Keywords: |
Alzheimer’s disease Epilepsy NREM sleep Sleep disorders Slow-wave sleep Subclinical epileptiform activity |
BORIS DOI: |
10.48350/165774 |
URI: |
https://boris.unibe.ch/id/eprint/165774 |
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