Impact of Latent Tuberculosis Infection on the Incidence of Type 2 Diabetes Mellitus in HIV-Infected Participants in the Swiss HIV Cohort Study.

Tepekule, Burcu; Kusejko, Katharina; Zeeb, Marius; Tarr, Philip E; Calmy, Alexandra; Battegay, Manuel; Furrer, Hansjakob; Cavassini, Matthias; Bernasconi, Enos; Notter, Julia; Günthard, Huldrych F; Nemeth, Johannes; Kouyos, Roger D (2022). Impact of Latent Tuberculosis Infection on the Incidence of Type 2 Diabetes Mellitus in HIV-Infected Participants in the Swiss HIV Cohort Study. The journal of infectious diseases, 225(12), pp. 2229-2234. Oxford University Press 10.1093/infdis/jiac054

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While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV (PHIV) in the Swiss HIV Cohort Study via time-dependent cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR=1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.

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