Tepekule, Burcu; Kusejko, Katharina; Zeeb, Marius; Tarr, Philip E; Calmy, Alexandra; Battegay, Manuel; Furrer, Hansjakob; Cavassini, Matthias; Bernasconi, Enos; Notter, Julia; Günthard, Huldrych F; Nemeth, Johannes; Kouyos, Roger D (2022). Impact of Latent Tuberculosis Infection on the Incidence of Type 2 Diabetes Mellitus in HIV-Infected Participants in the Swiss HIV Cohort Study. The journal of infectious diseases, 225(12), pp. 2229-2234. Oxford University Press 10.1093/infdis/jiac054
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While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV (PHIV) in the Swiss HIV Cohort Study via time-dependent cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR=1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Furrer, Hansjakob |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1537-6613 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Feb 2022 10:23 |
Last Modified: |
18 Feb 2023 00:25 |
Publisher DOI: |
10.1093/infdis/jiac054 |
PubMed ID: |
35172332 |
Uncontrolled Keywords: |
Heterologous immunity Inflammatory diseases Innate immunity Latent Tuberculosis Low-grade inflammation Type-2 Diabetes Mellitus |
BORIS DOI: |
10.48350/165783 |
URI: |
https://boris.unibe.ch/id/eprint/165783 |
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