The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review.

Siripanthong, Bhurint; Asatryan, Babken; Hanff, Thomas C; Chatha, Salman R; Khanji, Mohammed Y; Ricci, Fabrizio; Muser, Daniele; Ferrari, Victor A; Nazarian, Saman; Santangeli, Pasquale; Deo, Rajat; Cooper, Leslie T; Mohiddin, Saidi A; Chahal, C Anwar A (2022). The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury: State-of-the-Art Review. JACC. Basic to translational science, 7(3), pp. 294-308. Elsevier 10.1016/j.jacbts.2021.10.011

Preview

Text 1-s2.0-S2452302X21003181-main.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview

The mechanisms of coronavirus disease 2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.

Interest & Impact

Downloads

111 since deposited on 21 Feb 2022
54 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item