T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays

Martin, Stefan F; Esser, Philipp R; Schmucker, Sonja; Dietz, Lisa; Naisbitt, Dean J; Park, B Kevin; Vocanson, Marc; Nicolas, Jean-Francois; Keller, Monika; Pichler, Werner J; Peiser, Matthias; Luch, Andreas; Wanner, Reinhard; Maggi, Enrico; Cavani, Andrea; Rustemeyer, Thomas; Richter, Anne; Thierse, Hermann-Josef; Sallusto, Federica (2010). T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. Cellular and molecular life sciences, 67(24), pp. 4171-84. Basel: Springer 10.1007/s00018-010-0495-3

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Chemicals can elicit T-cell-mediated diseases such as allergic contact dermatitis and adverse drug reactions. Therefore, testing of chemicals, drugs and protein allergens for hazard identification and risk assessment is essential in regulatory toxicology. The seventh amendment of the EU Cosmetics Directive now prohibits the testing of cosmetic ingredients in mice, guinea pigs and other animal species to assess their sensitizing potential. In addition, the EU Chemicals Directive REACh requires the retesting of more than 30,000 chemicals for different toxicological endpoints, including sensitization, requiring vast numbers of animals. Therefore, alternative methods are urgently needed to eventually replace animal testing. Here, we summarize the outcome of an expert meeting in Rome on 7 November 2009 on the development of T-cell-based in vitro assays as tools in immunotoxicology to identify hazardous chemicals and drugs. In addition, we provide an overview of the development of the field over the last two decades.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Groux, Monika and Pichler, Werner Joseph

ISSN:

1420-682X

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:10

Last Modified:

04 May 2014 23:05

Publisher DOI:

10.1007/s00018-010-0495-3

PubMed ID:

20717835

Web of Science ID:

000284270000003

URI:

https://boris.unibe.ch/id/eprint/1664 (FactScience: 203520)

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