Pichler, Werner Joseph

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Pichler, Werner Joseph; Adam, Jacqueline; Watkins, Stephen; Wuillemin, Natascha Andrea; Yun, James Jin Sup; Yerly, Daniel (2015). Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors. International archives of allergy and immunology, 168(1), pp. 13-24. Karger 10.1159/000441280

Jörg-Walther, Lukas; Schnyder, Benno; Helbling, Arthur; Helsing, Karin; Schüller, Alexandra; Wochner, Annette; Pichler, Werner (2015). Flare-up reactions in severe drug hypersensitivity: infection or ongoing T-cell hyperresponsiveness. Clinical case reports, 3(10), pp. 798-801. Wiley 10.1002/ccr3.346

Wheatley, Lisa M; Plaut, Marshall; Schwaninger, Julie M; Banerji, Aleena; Castells, Mariana; Finkelman, Fred D; Gleich, Gerald J; Guttman-Yassky, Emma; Mallal, Simon A K; Naisbitt, Dean J; Ostrov, David A; Phillips, Elizabeth J; Pichler, Werner Joseph; Platts-Mills, Thomas A E; Roujeau, Jean-Claude; Schwartz, Lawrence B; Trepanier, Lauren A (2015). Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy. Journal of allergy and clinical immunology, 136(2), pp. 262-271. Mosby 10.1016/j.jaci.2015.05.027


Wuillemin, Natascha Andrea; Terracciano, Luigi; Beltraminelli, Helmut; Schlapbach, Christoph; Fontana, Stefano; Krähenbühl, Stephan; Pichler, Werner Joseph; Yerly, Daniel (2014). T cells infiltrate the liver and kill hepatocytes in HLA-B(∗)57:01-associated floxacillin-induced liver injury. American journal of pathology, 184(6), pp. 1677-1682. Elsevier 10.1016/j.ajpath.2014.02.018

Yun, James Jin Sup; Marcaida, Maria J; Eriksson, Klara K; Jamin, Heidi; Fontana, Stefano; Pichler, Werner Joseph; Yerly, Daniel (2014). Oxypurinol directly and immediately activates the drug-specific T cells via the preferential use of HLA-B*58:01. Journal of immunology, 192(7), pp. 2984-2993. American Association of Immunologists 10.4049/jimmunol.1302306

Srinoulprasert, Yuttana; Pichler, Werner Joseph (2014). Enhancement of Drug-Specific Lymphocyte Proliferation Using CD25-Depleted CD3(+) Effector Cells. International archives of allergy and immunology, 163(3), pp. 198-205. Karger 10.1159/000358491

Demoly, P.; Adkinson, N. F.; Brockow, K.; Castells, M.; Chiriac, A. M.; Greenberger, P. A.; Khan, D. A.; Lang, D. M.; Park, H.-S.; Pichler, Werner Joseph; Sanchez-Borges, M.; Shiohara, T.; Thong, B. Y.-H. (2014). International Consensus on drug allergy. Allergy, 69(4), pp. 420-437. Wiley-Blackwell 10.1111/all.12350

Pichler, Werner Joseph; Watkins, Stephan Lloyd (2014). Interaction of small molecules with specific immune receptors: the p-i concept and its consequences. Current Immunology Reviews, 10(1), pp. 7-18. Bentham Science Publishers

Adam, Jacqueline; Wuillemin, Natascha Andrea; Watkins, Stephan Lloyd; Jamin, Heidi; Eriksson, Klara Kristin; Villiger, Peter; Fontana, Stefano; Pichler, Werner Joseph; Yerly, Daniel (2014). Abacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responses. PLoS ONE, 9(4), e95339. Public Library of Science 10.1371/journal.pone.0095339


Yun, J,; Mattsson, J,; Schnyder, K,; Fontana, S,; Largiadèr, C, R,; Pichler, W, J,; Yerly, D, (2013). Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response. Clinical and experimental allergy, 43(11), pp. 1246-1255. Blackwell Scientific Publications 10.1111/cea.12184

Pichler, Werner J.; Schnyder, K. (2013). Medikamentenallergie: Diagnostische Möglichkeiten mit In-vitro-Methoden. Allergologie, 36(10), pp. 436-443. Dustri-Verlag 10.5414/ALX01602

Porebski, G.; Pecaric-Petkovic, T.; Groux-Keller, M.; Bosak, M.; Kawabata, T. T.; Pichler, W. J. (2013). In vitro drug causality assessment in Stevens-Johnson syndrome - alternatives for lymphocyte transformation test. Clinical and experimental allergy, 43(9), pp. 1027-1037. Blackwell Scientific Publications 10.1111/cea.12145

Schnyder, Benno; Adam, Jacqueline; Rauch, Andri; Thurnheer, Maria C.; Pichler, Werner J. (2013). Letter to the editor: HLA-B*57:01(+) abacavir-naive individuals have specific T cells but no patch test reactivity. Journal of allergy and clinical immunology, 132(3), pp. 756-758. Mosby 10.1016/j.jaci.2013.04.013

Watkins, Stephan; Pichler, Werner J (2013). T cell receptor variable β20-1 harbors a nucleotide binding pocket in the CDR2β loop. Open Journal of Immunology, 3(3), pp. 165-174. Scientific Research Publishing 10.4236/oji.2013.33021

Schnyder, B.; Porebski, G.; Pichler, W. J. (2013). Allergy workup of severe cutaneous adverse drug reactions: a light at the end of the tunnel? British journal of dermatology, 168(3), pp. 463-464. Wiley-Blackwell 10.1111/bjd.12253

Schnyder, Benno; Pichler, Werner J. (2013). Allergy to sulfonamides. Journal of allergy and clinical immunology, 131(1), 256-257e.5. Mosby 10.1016/j.jaci.2012.10.003

Watkins, Stephan; Pichler, Werner J. (2013). Sulfamethoxazole induces a switch mechanism in T cell receptors containing TCRVβ20-1, altering pHLA recognition. PLoS ONE, 8(10), e76211. Public Library of Science 10.1371/journal.pone.0076211

Pichler, Werner; Ring, Johannes (2013). In Memoriam - A Tribute to Alain L. de Weck. International archives of allergy and immunology, 162(1), pp. 97-98. Karger 10.1159/000351773

Pichler, Werner J. (2013). Consequences of drug binding to immune receptors: Immune stimulation following pharmacological interaction with immune receptors (T-cell receptor for antigen or human leukocyte antigen) with altered peptide-human leukocyte antigen or peptide. Dermatologica Sinica, 31(4), pp. 181-190. Elsevier 10.1016/j.dsi.2013.09.005

Watkins, Stephan; Pichler, Werner J. (2013). Activating interactions of sulfanilamides with T cell receptors. Open Journal of Immunology, 3(3), pp. 139-157. Scientific Research Publishing 10.4236/oji.2013.33019

Adam, Jacqueline; Wuillemin, Natascha Andrea; Schnyder, K; Yerly, Daniel; Pichler, Werner Joseph; Yawalkar, Nikhil; Schlapbach, Christoph (2013). Possible involvement of Ambroxol as trigger of an erythema exsudativum multiforme majus/Stevens-Johnson Syndrome overlap. Dermatologica Helvetica, 25(6). Karger

Adam, Jacqueline; Wuillemin, Natascha Andrea; Schnyder, K.; Yerly, Daniel; Pichler, Werner Joseph; Yawalkar, Nikhil; Schlapbach, Christoph (2013). CD8+ T cells and NK cells from blister fluid of an EEM/SJS overlap highly express Fas ligand and Granulysin (Unpublished). In: Gemeinsame Jahresversammlung der Schweizerischen Gesellschaft für Allergologie und Immunologie und der Gesellschaft für Pneumologie. Bern. 17. - 19.04.2013.


Daubner, B; Groux-Keller, M; Hausmann, O V; Kawabata, T; Naisbitt, D J; Park, B K; Wendland, T; Lerch, M; Pichler, W J (2012). Multiple drug hypersensitivity: normal Treg cell function but enhanced in vivo activation of drug-specific T cells. Allergy, 67(1), pp. 58-66. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02720.x

Kopac, P; Rudin, M; Gentinetta, T; Gerber, R; Pichler, Ch; Hausmann, O; Schnyder, B; Pichler, W J (2012). Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy. Allergy, 67(2), pp. 280-5. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02744.x

Hausmann, O; Schnyder, B; Pichler, W J (2012). Etiology and pathogenesis of adverse drug reactions. Chemical immunology and allergy, 97, pp. 32-46. Basel: Karger

Popov, Todor A; Ledford, Dennis; Lockey, Richard; Pawankar, Ruby; Li, James T; Park, Hae Sim; Pichler, Werner; Perez, Noel Rodriguez; Tassinari, Paolo; Braido, Fulvio; Bahna, Sami; Solé, Dirceu; Katelaris, Connie; Holgate, Stephen; World Allergy Organization Education Council, (2012). Maintenance of skills, competencies, and performance in allergy and clinical immunology: time to lay the foundation for a universal approach. World Allergy Organization journal, 5(4), pp. 45-51. Hagerstown, Md.: Wolters Kluwer Health Lippincott Williams & Wilkins

Yun, J; Adam, J; Yerly, D; Pichler, W J (2012). Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA. Allergy, 67(11), pp. 1338-46. Oxford: Wiley-Blackwell 10.1111/all.12008

Adam, Jacqueline; Eriksson, Klara K; Schnyder, Benno; Fontana, Stefano; Pichler, Werner J; Yerly, Daniel (2012). Avidity determines T-cell reactivity in abacavir hypersensitivity. European journal of immunology, 42(7), pp. 1706-16. Weinheim: Wiley-VCH 10.1002/eji.201142159

Schnyder, Benno; Pichler, Werner J (2012). Nonimmediate drug allergy: diagnostic benefit of skin testing and practical approach. Journal of allergy and clinical immunology, 129(4), pp. 1170-1. St. Louis, Mo.: Mosby 10.1016/j.jaci.2012.02.029


Gentinetta, Thomas; Pecaric-Petkovic, Tatjana; Wan, Daniel; Falcone, Franco H; Dahinden, Clemens A; Pichler, Werner J; Hausmann, Oliver V (2011). Individual IL-3 priming is crucial for consistent in vitro activation of donor basophils in patients with chronic urticaria. Journal of allergy and clinical immunology, 128(6), 1227-1234.e5. St. Louis, Mo.: Mosby 10.1016/j.jaci.2011.07.021

Schlapbach, C; Zawodniak, A; Irla, N; Adam, J; Hunger, R E; Yerly, D; Pichler, W J; Yawalkar, N (2011). NKp46+ cells express granulysin in multiple cutaneous adverse drug reactions. Allergy, 66(11), pp. 1469-76. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02677.x

Wendland, Thomas; Daubner, Barbara; Pichler, Werner J (2011). Ceftobiprole associated agranulocytosis after drug rash with eosinophilia and systemic symptoms induced by vancomycin and rifampicin. British journal of clinical pharmacology, 71(2), pp. 297-300. Oxford: Wiley-Blackwell 10.1111/j.1365-2125.2010.03832.x

Pichler, Werner J; Daubner, Barbara; Kawabata, Tom (2011). Drug hypersensitivity: flare-up reactions, cross-reactivity and multiple drug hypersensitivity. Journal of dermatology, 38(3), pp. 216-21. Richmond (Aus.): Wiley 10.1111/j.1346-8138.2010.01142.x

Pichler, Werner J; Naisbitt, Dean J; Park, B Kevin (2011). Immune pathomechanism of drug hypersensitivity reactions. Journal of allergy and clinical immunology, 127(3 Suppl), S74-81. St. Louis, Mo.: Mosby 10.1016/j.jaci.2010.11.048

McCormack, Mark; Alfirevic, Ana; Bourgeois, Stephane; Farrell, John J; Kasperavičiūtė, Dalia; Carrington, Mary; Sills, Graeme J; Marson, Tony; Jia, Xiaoming; de Bakker, Paul I W; Chinthapalli, Krishna; Molokhia, Mariam; Johnson, Michael R; O'Connor, Gerard D; Chaila, Elijah; Alhusaini, Saud; Shianna, Kevin V; Radtke, Rodney A; Heinzen, Erin L; Walley, Nicole; ... (2011). HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. New England journal of medicine NEJM, 364(12), pp. 1134-43. Waltham, Mass.: Massachusetts Medical Society MMS 10.1056/NEJMoa1013297

Elsheikh, Ayman; Castrejon, Luis; Lavergne, Sidonie N; Whitaker, Paul; Monshi, Manal; Callan, Hayley; El-Ghaiesh, Sabah; Farrell, John; Pichler, Werner J; Peckham, Daniel; Park, B Kevin; Naisbitt, Dean J (2011). Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis. Journal of allergy and clinical immunology, 127(6), 1543-51.e3. St. Louis, Mo.: Mosby 10.1016/jaci.2010.12.1119

Heinzerling, Lucie M; Pichler, Werner; Anliker, Mark D (2011). Acute generalized exanthematous pustulosis induced by methylphenidate: a new adverse effect. Archives of dermatology, 147(7), pp. 872-3. Chicago, Ill.: American Medical Association 10.1001/archdermatol.2011.179

Caubet, Jean-Christoph; Pichler, Werner J; Eigenmann, Philippe A (2011). Educational case series: Mechanisms of drug allergy. Pediatric allergy and immunology, 22(6), pp. 559-67. Oxford: Wiley-Blackwell 10.1111/j.1399-3038.2011.01183.x

Romano, Antonino; Pichler, Werner J; Blanca, Miguel (2011). Highlights of the 4th Drug Hypersensitivity Meeting--Rome, April 22-25, 2010. Preface. Journal of allergy and clinical immunology, 127(3 Suppl), S59. St. Louis, Mo.: Mosby 10.1016/j.jaci.2010.12.1090

Porebski, G; Gschwend-Zawodniak, A; Pichler, W J (2011). In vitro diagnosis of T cell-mediated drug allergy. Clinical and experimental allergy, 41(4), pp. 461-70. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2222.2011.03701.x

Gentinetta, T; Hausmann, OV; Pichler, WJ (2011). Basophilehn-Aktivierungstest an der Schnittstelle von Serologie und zellulärer Diagnostik. In: (pp. 13-15). Pipette Okt 2011

Fricker, M; Pichler, WJ; Helbling, A (2011). Prostaglandinsynthesehemmer-Intoleranz. In: Schweiz Med Forum 2011

Pichler, W; Wendland, T; Hausmann, OV; Schnyder, B; Fricker, M; Pichler, C; Helbling, A (2011). DRESS (Drug Rash with Eosinophilia and Systemic Symptoms). Eine Schwere, oft verkannte Medikamentenallergie. In: (pp. 879-884). Schweiz Med Forum 2011


Zawodniak, Anna; Lochmatter, Priska; Yerly, Daniel; Kawabata, Thomas; Lerch, Marianne; Yawalkar, Nikhil; Pichler, Werner Joseph (2010). In vitro detection of cytotoxic T and NK cells in peripheral blood of patients with various drug-induced skin diseases. Allergy, 65(3), pp. 376-384. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2009.02180.x

Keller, M; Lerch, M; Britschgi, M; Tâche, V; Gerber, B O; Lüthi, M; Lochmatter, P; Kanny, G; Bircher, A J; Christiansen, C; Pichler, W J (2010). Processing-dependent and -independent pathways for recognition of iodinated contrast media by specific human T cells. Clinical and experimental allergy, 40(2), pp. 257-68. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2222.2009.03425.x

Hausmann, O; Schnyder, B; Pichler, WJ (2010). Drug hypersensitivity reactions involving skin. Handbook of experimental pharmacology(196), pp. 29-55. Berlin: Springer

Martin, Stefan F; Esser, Philipp R; Schmucker, Sonja; Dietz, Lisa; Naisbitt, Dean J; Park, B Kevin; Vocanson, Marc; Nicolas, Jean-Francois; Keller, Monika; Pichler, Werner J; Peiser, Matthias; Luch, Andreas; Wanner, Reinhard; Maggi, Enrico; Cavani, Andrea; Rustemeyer, Thomas; Richter, Anne; Thierse, Hermann-Josef; Sallusto, Federica (2010). T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. Cellular and molecular life sciences, 67(24), pp. 4171-84. Basel: Springer 10.1007/s00018-010-0495-3

Elsheikh, Ayman; Lavergne, Sidonie N; Castrejon, J Luis; Farrell, John; Wang, Haiyi; Sathish, Jean; Pichler, Werner J; Park, B Kevin; Naisbitt, Dean J (2010). Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism. Journal of immunology, 185(11), pp. 6448-60. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.1000889

Cernadas, J. R.; Brockow, K.; Romano, A.; Aberer, W.; Torres, M. J.; Bircher, A.; Campi, P.; Sanz, M. L.; Castells, M.; Demoly, P.; Pichler, Werner Joseph; , ; , (2010). General considerations on rapid desensitization for drug hypersensitivity - a consensus statement. Allergy, 65(11), pp. 1357-1366. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2010.02441.x

Pichler, (2010). The area of drug hypersensitivity has been widely neglected not least because it is a complex area. Preface. Medical clinics of North America, 94(4), xv-vi. Philadelphia, Pa.: Elsevier 10.1016/j.mcna.2010.04.008

Zawodniak, A.; Lochmatter, P.; Beeler, A.; Pichler, W. J. (2010). Cross-reactivity in drug hypersensitivity reactions to sulfasalazine and sulfamethoxazole. International archives of allergy and immunology, 153(2), pp. 152-156. Basel: Karger 10.1159/000312632

Castrejon, J Luis; Berry, Neil; El-Ghaiesh, Sabah; Gerber, Basil; Pichler, Werner J; Park, B Kevin; Naisbitt, Dean J (2010). Stimulation of human T cells with sulfonamides and sulfonamide metabolites. Journal of allergy and clinical immunology, 125(2), 411-418.e4. St. Louis, Mo.: Mosby 10.1016/j.jaci.2009.10.031

Pichler, Werner Joseph (2010). Arzneimittelunverträglichkeiten - Notfälle vermeiden. In: HNO-Nachrichten

Pichler, Werner Joseph (2010). Guest Editor of Medical Clinics of North America. In: Drug Hypersensitivity

Cernadas, JR; Brockow, K; Romano, A; Aberer, W; Torres, MJ; Bircher, A; Campi, P; Sanz, ML; Castells, M; Emoly, P; Pichler, WJ (2010). For the European Network of Drug Allergy and the EAACI interest group on drug hypersensitivity. General considerations on rapid desensitization for drug hypersenitivity - a consensus statement. In: Allergy

Pichler, WJ; Adam, J; Daubner, B; Gentinetta, T; Keller, M; Yerly, D (2010). Drug hypersensitivity reactions: pathomechansim and clinical symptoms. Medical clinics of North America, 94(4), pp. 645-664. Philadelphia, Pa.: Elsevier 10.1016/j.mcna.2010.04.003

Hausmann, Oliver V; Seitz, Michael; Villiger, Peter M; Pichler, Werner J (2010). The complex clinical picture of side effects to biologicals. Medical clinics of North America, 94(4), 791-804, xi-ii. Philadelphia, Pa.: Elsevier 10.1016/j.mcna.2010.03.001


Brockow, K; Romano, A; Aberer, W; Bricher, AJ; Barbaud, A; Bonadonna, P; Faria, E; Kanny, G; Lerch, M; Pichler, WJ; Ring, J; Rodrigues Cernadas, J; Tomaz, E; Demoly, P; Christiansen, C (2009). Skin testing in patients with hypersensitivity reactions to iodinated contrast media: A european multicenter study. Allergy, 64(2), pp. 234-41. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2008.01832.x

Cook, Stéphane; Ladich, Elena; Nakazawa, Gaku; Eshtehardi, Parham; Neidhart, Michel; Vogel, Rolf; Togni, Mario; Wenaweser, Peter; Billinger, Michael; Seiler, Christian; Gay, Steffen; Meier, Bernhard; Pichler, Werner J; Jüni, Peter; Virmani, Renu; Windecker, Stephan (2009). Correlation of intravascular ultrasound findings with histopathological analysis of thrombus aspirates in patients with very late drug-eluting stent thrombosis. Circulation, 120(5), pp. 391-399. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCULATIONAHA.109.854398

Mennicke, M; Zawodniak, A; Keller, M; Wilkens, L; Yawalkar, N; Stickel, F; Keogh, A; Inderbitzin, D; Candinas, D; Pichler, W J (2009). Fulminant liver failure after vancomycin in a sulfasalazine-induced DRESS syndrome: fatal recurrence after liver transplantation. American journal of transplantation, 9(9), pp. 2197-202. Oxford: Wiley-Blackwell 10.1111/j.1600-6143.2009.02788.x

Steiner, Urs C; Gentinetta, Thomas; Hausmann, Oliver; Pichler, Werner J (2009). IgE-mediated anaphylaxis to intraarticular glucocorticoid preparations. AJR, American journal of roentgenology, 193(2), W156-7. Leesburg, Va.: American Roentgen Ray Society 10.2214/AJR.09.2495

Bergmann-Hug, K; Wirth, R; Henseler, M; Helbling, A; Pichler, W J; Schnyder, B (2009). Effect of natural seasonal pollen exposure and repeated nasal allergen provocations on elevation of exhaled nitric oxide. Allergy, 64(11), pp. 1629-34. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2009.02087.x

Lochmatter, Priska; Zawodniak, Anna; Pichler, Werner J (2009). In vitro tests in drug hypersensitivity diagnosis. Immunology and allergy clinics of North America, 29(3), pp. 537-54. Philadelphia, Pa.: Elsevier 10.1016/j.iac.2009.04.009

Pichler, (2009). Preface. Drug hypersensitivity. Immunology and allergy clinics of North America, 29(3), xv-xvi. Philadelphia, Pa.: Elsevier 10.1016/j.iac.2009.06.001

Pichler, W J (2009). [Intolerance as consequence of hyperreactivity]. Praxis - schweizerische Rundschau für Medizin, 98(7), pp. 389-94. Bern: Huber

Lochmatter, P; Beeler, A; Kawabata, T T; Gerber, B O; Pichler, W J (2009). Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in patients with delayed-type drug hypersensitivity. Allergy, 64(9), pp. 1269-78. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2009.01985.x

Schnyder, Benno; Pichler, Werner J (2009). Mechanisms of drug-induced allergy. Mayo Clinic proceedings, 84(3), pp. 268-72. New York, N.Y.: Elsevier 10.4065/84.3.268

Bousquet, P-J; Demoly, P; Romano, A; Aberer, W; Bircher, A; Blanca, M; Brockow, K; Pichler, W; Torres, M J; Terreehorst, I; Arnoux, B; Atanaskovic-Markovic, M; Barbaud, A; Bijl, A; Bonadonna, P; Burney, P G; Caimmi, S; Canonica, G W; Cernadas, J; Dahlen, B; ... (2009). Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project. Allergy, 64(2), pp. 194-203. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2008.01944.x

Stein, MR; Nelson, RP; Church, JA; Wassermann, RL; Borte, M; Vermylen, C; Pichler, WJ (2009). Safety and efficacy of Privigen, a novel 10% liquid immunoglobulin preparation for intravenous use, in patients with primary immunodeficienceis. Journal of clinical immunology, 29(1), pp. 137-144. New York, N.Y.: Springer 10.1007/s10875-008-9231-2

Zawodniak, Anna; Pichler, Werner J. (2009). Immunological Principles of Drug Hypersensitivity. In: Pawankar, Ruby; Holgate, Stephen T.; Rosenwasser, Lanny J. (eds.) Clinical Manifestations. Allergy Frontiers: Vol. 3 (pp. 393-410). Tokyo: Springer 10.1007/978-4-431-88317-3_25


Yerly, Daniel; Heckerman, David; Allen, Todd; Suscovich, Todd J; Jojic, Nebojsa; Kadie, Carl; Pichler, Werner J; Cerny, Andreas; Brander, Christian (2008). Design, expression, and processing of epitomized hepatitis C virus-encoded CTL epitopes. Journal of immunology, 181(9), pp. 6361-70. Bethesda, Md.: American Association of Immunologists

Weber-Mani, U; Pichler, W J (2008). Anaphylactic shock after intradermal testing with betalactam antibiotics. Allergy, 63(6), p. 785. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2008.01682.x

Demoly, P; Pichler, W; Pirmohamed, M; Romano, A (2008). Important questions in Allergy: 1--drug allergy/hypersensitivity. Allergy, 63(5), pp. 616-9. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2008.01693.x

Yerly, Daniel; Heckerman, David; Allen, Todd M; Chisholm, John V; Faircloth, Kellie; Linde, Caitlyn H; Frahm, Nicole; Timm, Joerg; Pichler, Werner J; Cerny, Andreas; Brander, Christian (2008). Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance. Journal of virology, 82(6), pp. 3147-53. Baltimore: American Society for Microbiology 10.1128/JVI.02252-07

Beeler, A; Zaccaria, L; Kawabata, T; Gerber, B O; Pichler, W J (2008). CD69 upregulation on T cells as an in vitro marker for delayed-type drug hypersensitivity. Allergy, 63(2), pp. 181-8. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2007.01516.x


Pichler, WJ (2007). Allergologie: Aus Fehlern lernen. Schlaglichter 2006. Schweizerisches Medizin-Forum SMF / Swiss medical forum / Forum médical suisse FMS(7), pp. 5-6. Basel: EMH Editores Medicorum Helveticorum

Posadas, SJ; Pichler, WJ (2007). Delayed drug hypersensitivity reactions - new concepts. Clinical and experimental allergy, -37(7), pp. 989-99. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2222.2007.02742.x

Pichler, WJ (2007). Hapten-Modell contra p-i-Konzept. Allergo-Journal - interdisziplinäre Zeitschrift für Allergologie und Umweltmedizin, 16(4), pp. 238-239. München: Urban und Vogel 10.1007/BF03371967

Lerch, M; Keller, M; Britschgi, M; Kanny, G; Tache, V; Schmid, D.A.; Beeler, A; Gerber, BO; Luethi, M; Bricher, AJ; Christiansen, C; Pichler, WJ (2007). Cross-reactivity patterns of T cells specific for iodinated contrast media. Journal of allergy and clinical immunology, -119(6), pp. 1529-36. St. Louis, Mo.: Mosby 10.1016/j.jaci.2007.02.007

Pichler, WJ (2007). Predicting Drug Hypersensitivity by In Vitro Tests. ALTEX - Alternativen zu Tierexperimenten(2007), pp. 1-2. Heidelberg: Spektrum Akademischer Verlag

Berger, D; Pichler, WJ; Savic, S; Schoenenberger, R; Borer, H (2007). Status febrilis, pneumonisches Infiltrat und Eosinophilie. Praxis - schweizerische Rundschau für Medizin(96), pp. 1543-1547. Bern: Huber

Gerber, BO; Pichler, WJ (2007). The p-i concept: Evidence and implications. In: (pp. 66-73). Basel: Karger

Pichler, WJ; Campi, P (2007). Adverse side effects to biological agents. In: (pp. 151-165). Basel: Karger

Pichler, WJ (2007). Drug Hypersensitivity Reactions: Classification and relationship to T cell activation. In: (pp. 168-189). Basel: Karger

Keller, M; Spanou, Z; Pichler, WJ (2007). Drug-induced interstitial nephritis. In: (pp. 295-305). Basel: Karger

Beeler, A; Pichler, WJ (2007). In vitro tests of T cell mediated drug hypersensitivity. In: (pp. 380-390). Basel: Karger


Spanou, Zoi; Keller, Monika; Britschgi, Markus; Yawalkar, Nikhil; Fehr, Thomas; Neuweiler, Jörg; Gugger, Mathias; Mohaupt, Markus; Pichler, Werner J (2006). Involvement of drug-specific T cells in acute drug-induced interstitial nephritis. Journal of the American Society of Nephrology, 17(10), pp. 2919-27. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1681/ASN.2006050418

Pichler, Werner J; Beeler, Andreas; Keller, Monika; Lerch, Marianne; Posadas, Sinforiano; Schmid, Daphne; Spanou, Zoi; Zawodniak, Anna; Gerber, Basil (2006). Pharmacological interaction of drugs with immune receptors: the p-i concept. Allergology International, 55(1), pp. 17-25. Carlton (Aus.): Blackwell Science

Buettiker, U; Keller, M; Pichler, W J; Braathen, L R; Yawalkar, N (2006). Oral prednisolone induced acute generalized exanthematous pustulosis due to corticosteroids of group A confirmed by epicutaneous testing and lymphocyte transformation tests. Dermatology, 213(1), pp. 40-3. Basel: Karger 10.1159/000092837

Schmid, Daphné Anne; Depta, Jan Paul Heribert; Lüthi, Michael; Pichler, Werner Joseph (2006). Transfection of drug-specific T-cell receptors into hybridoma cells: tools to monitor drug interaction with T-cell receptors and evaluate cross-reactivity to related compounds. Molecular pharmacology, 70(1), pp. 356-65. Bethesda, Md.: American Society for Pharmacology and Experimental Therapeutics 10.1124/mol.105.021576

Gerber, Basil O; Pichler, Werner J (2006). Noncovalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions. AAPS journal, 8(1), E160-5. Arlington, Va.: Springer-Verlag 10.1208/aapsj080119

Beeler, Andreas; Engler, Olivier; Gerber, Basil O; Pichler, Werner J (2006). Long-lasting reactivity and high frequency of drug-specific T cells after severe systemic drug hypersensitivity reactions. Journal of allergy and clinical immunology, 117(2), pp. 455-62. St. Louis, Mo.: Mosby 10.1016/j.jaci.2005.10.030

Gex-Collet, C; Imhof, L; Brattström, A; Pichler, W J; Helbling, A (2006). The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions. Journal of investigational allergology & clinical immunology, 16(3), pp. 156-61. Barcelona: Esmon Publicidad

Schmid, Daphné Anne; Campi, Paolo; Pichler, Werner Joseph (2006). Hypersensitivity reactions to quinolones. Current pharmaceutical design, 12(26), pp. 3313-26. Hilversum: Bentham Science Publishers

Pichler, W J (2006). Adverse side-effects to biological agents. Allergy, 61(8), pp. 912-20. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.20006.01058.x

Schmid, D A; Depta, J P H; Pichler, W J (2006). T cell-mediated hypersensitivity to quinolones: mechanisms and cross-reactivity. Clinical and experimental allergy, 36(1), pp. 59-69. Oxford: Blackwell Scientific Publications 10.1111/j.1365-2222.2006.02402.x

Wu, Ying; Sanderson, Joseph P; Farrell, John; Drummond, Nicola S; Hanson, Anita; Bowkett, Elizabeth; Berry, Neil; Stachulski, Andrew V; Clarke, Stephen E; Pichler, Werner J; Pirmohamed, Munir; Park, B Kevin; Naisbitt, Dean J (2006). Activation of T cells by carbamazepine and carbamazepine metabolites. Journal of allergy and clinical immunology, 118(1), pp. 233-41. St. Louis, Mo.: Mosby 10.1016/j.jaci.2006.03.005

Kapp, Alexander; Pichler, Werner J (2006). Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study. International journal of dermatology, 45(4), pp. 469-74. Oxford: Blackwell Science 10.1111/j.1365-4632.2005.02609.x

Beeler, A; Pichler, WJ (2006). In vitro tests of T cell-mediated drug hypersensitivity. Clinical immunology, 2(6), pp. 887-900. San Diego, Calif.: Elsevier

Jeger, F; Pichler, WJ; Helbling, A (2006). Wiederholte Unverträglichkeitsreaktionen auf Lokalanästhetika gibt es eine Erklärung? Allergologie, 29(2), pp. 39-45. München-Deisenhofen: Dustri-Verlag

Hug, K; Pichler, WJ (2006). Die spezifische Immuntherapie - subkutan und sublingual. Medical journal TMJ - Schweizer Zeitschrift für Innere Medizin(2) Neuhausen (CH): Rosenfluh


Hunziker, Isabelle P.; Grabscheid, Benno; Zurbriggen, Rinaldo; Glück, Reinhard; Pichler, Werner J.; Cerny, Andreas (2002). In vitro studies of core peptide‐bearing immunopotentiating reconstituted influenza virosomes as a non‐live prototype vaccine against hepatitis C virus. International immunology, 14(6), pp. 615-626. Oxford University Press 10.1093/intimm/dxf026


Von Greyerz, Salome; Bültemann, Gregor; Schnyder, Karin; Burkhart, Christoph; Lotti, Barbara; Hari, Yvonne; Pichler, Werner J. (2001). Degeneracy and additional alloreactivity of drug-specific human αβ+ T cell clones. International immunology, 13(7), pp. 877-885. Oxford University Press 10.1093/intimm/13.7.877


Zanni, M P; Von Greyerz, S; Schnyder, B; Wendland, T; Pichler, W J (1998). Allele-unrestricted presentation of lidocaine by HLA-DR molecules to specific alphabeta+ T cell clones. International immunology, 10(4), pp. 507-515. Oxford University Press 10.1093/intimm/10.4.507

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