Jakob, Julian; Stalder, Odile; Tal, Kali; Pruvot, Etienne; Pletcher, Mark J; Rana, Jamal S; Sidney, Stephen; Auer, Reto (2022). Association between Current and Cumulative Cannabis use and Heart Rate. The Coronary Artery Risk Development in Young Adults (CARDIA) Study. American journal of medicine, 135(7), 871-878.e14. Elsevier 10.1016/j.amjmed.2022.01.057
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BACKGROUND
Resting heart rate can predict cardiovascular disease. Heart rate increases with tobacco smoking but its association with cannabis use is unclear. We studied the association between current and cumulative cannabis use and heart rate.
METHODS
We used data from the Coronary Artery Risk Development in Young Adults (CARDIA) Study, a large prospective cohort of 5,115 Black and white women and men followed over 30 years. We explored the association between cannabis exposure and heart rate, adjusted for demographic factors, cardiovascular risk factors, alcohol and other illicit drug use, physical activity, and beta-blockers, in mixed longitudinal models censoring participants with cardiovascular disease.
RESULTS
CARDIA participants contributed to 35,654 individual exams over 30 years. At the Year 30 exam, 471/3,269 (14%) currently used cannabis. In multivariable adjusted models, compared to no current use, using cannabis five times per month was associated with lower heart rate of -0.7 bpm (95% CI: -1.0 to -0.3), and daily use with lower heart rate of -2.1 bpm (95% CI: -3.0 to -1.3, overall p<0.001). Cumulative exposure to cannabis use was not associated with heart rate.
CONCLUSION
Recent current cannabis use was associated with lower resting heart rate. The findings appeared to be transient, as past cumulative exposure to cannabis was not associated with heart rate. This adds to the growing body of evidence suggesting a lack of deleterious association of cannabis use at a level typical of the general population on surrogate outcomes of cardiovascular disease.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM) 04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR) 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine |
UniBE Contributor: |
Jakob, Julian, Stalder, Odile, Tal, Kali, Auer, Reto |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0002-9343 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
07 Mar 2022 10:50 |
Last Modified: |
20 Feb 2024 14:16 |
Publisher DOI: |
10.1016/j.amjmed.2022.01.057 |
PubMed ID: |
35245494 |
Uncontrolled Keywords: |
Cannabis Cardiovascular disease Heart rate |
BORIS DOI: |
10.48350/166580 |
URI: |
https://boris.unibe.ch/id/eprint/166580 |
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