Photoremovable Protecting Groups: Across the Light Spectrum to Near-Infrared Absorbing Photocages

Štacko, Peter; Šolomek, Tomáš (2021). Photoremovable Protecting Groups: Across the Light Spectrum to Near-Infrared Absorbing Photocages. CHIMIA, 75(10), pp. 873-881. Schweizerische Chemische Gesellschaft 10.2533/chimia.2021.873

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We discuss the past decade of progress in the field of photoremovable protecting groups that allowed the development of photocages activatable by near-IR light and highlight the individual conceptual advancements that lead to general guidelines to design new such photoremovable protecting groups. We emphasize the importance of understanding the individual photochemical reaction mechanisms that was necessary to achieve this progress and provide an outlook of the subsequent steps to facilitate a swift translation of this research into clinical praxis. Since this issue of CHIMIA is dedicated to the late Prof. Thomas Bally, we decided to provide a personal perspective on the field to which he contributed himself. We tried to write this review with the general readership of CHIMIA in mind in a hope to pay a tribute to the extraordinary dedication and clarity with which Thomas Bally used to explain abstract chemical concepts to his students or colleagues. We are uncertain whether we matched such challenge but we believe that he would have liked such approach very much.

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