Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017.

Hierweger, Melanie M; Koch, Michel C; Rupp, Melanie; Maes, Piet; Di Paola, Nicholas; Bruggmann, Rémy; Kuhn, Jens H; Schmidt-Posthaus, Heike; Seuberlich, Torsten (2021). Novel Filoviruses, Hantavirus, and Rhabdovirus in Freshwater Fish, Switzerland, 2017. Emerging infectious diseases, 27(12), pp. 3082-3091. Centers for Disease Control and Prevention 10.3201/eid2712.210491

Full text not available from this repository. (Request a copy)

European perch (Perca fluviatilis) are increasingly farmed as a human food source. Viral infections of European perch remain largely unexplored, thereby putting farm populations at incalculable risk for devastating fish epizootics and presenting a potential hazard to consumers. To address these concerns, we applied metatranscriptomics to identify disease-associated viruses in European perch farmed in Switzerland. Unexpectedly, in clinically diseased fish we detected novel freshwater fish filoviruses, a novel freshwater fish hantavirus, and a previously unknown rhabdovirus. Hantavirus titers were high, and we demonstrated virus in macrophages and gill endothelial cells by using in situ hybridization. Rhabdovirus titers in organ samples were low, but virus could be isolated on cell culture. Our data add to the hypothesis that filoviruses, hantaviruses, and rhabdoviruses are globally distributed common fish commensals, pathogens, or both. Our findings shed new light on negative-sense RNA virus diversity and evolution.

Item Type:

Journal Article (Original Article)


05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Center for Fish and Wildlife Health (FIWI)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Hierweger, Melanie Michaela, Koch, Michel Christoph, Rupp, Melanie, Schmidt-Posthaus, Heike, Seuberlich, Torsten


600 Technology > 630 Agriculture




Centers for Disease Control and Prevention




Torsten Seuberlich

Date Deposited:

17 Mar 2022 09:36

Last Modified:

05 Dec 2022 16:15

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

European perch Switzerland filovirus freshwater fish hantavirus rhabdovirus viruses


Actions (login required)

Edit item Edit item
Provide Feedback