Kurmann, Christoph C; Kaesmacher, Johannes; Cooke, Daniel L; Psychogios, Marios; Weber, Johannes; Lopes, Demetrius K; Albers, Gregory W; Mordasini, Pasquale (2023). Evaluation of time-resolved whole brain flat panel detector perfusion imaging using RAPID ANGIO in patients with acute stroke: comparison with CT perfusion imaging. Journal of neurointerventional surgery, 15(4), pp. 387-392. BMJ Publishing Group 10.1136/neurintsurg-2021-018464
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BACKGROUND
In contrast to conventional CT perfusion (CTP) imaging, flat panel detector CT perfusion (FD-CTP) imaging can be acquired directly in the angiosuite.
OBJECTIVE
To evaluate time-resolved whole brain FD-CTP imaging and assess clinically important qualitative and quantitative perfusion parameters in correlation with previously acquired conventional CTP using the new RAPID for ANGIO software.
METHODS
We included patients with internal carotid artery occlusions and M1 or M2 occlusions from six centers. All patients underwent mechanical thrombectomy (MT) with preinterventional conventional CTP and FD-CTP imaging. Quantitative performance was determined by comparing volumes of infarct core, penumbral tissue, and mismatch. Eligibility for MT according to the perfusion imaging criteria of DEFUSE 3 was determined for each case from both conventional CTP and FD-CTP imaging.
RESULTS
A total of 20 patients were included in the final analysis. Conventional relative cerebral blood flow (rCBF) <30% and FD-CTP rCBF <45% showed good correlation (R2=0.84). Comparisons of conventional CTP Tmax >6 s versus FD-CTP Tmax >6 s and CTP mismatch versus FD-CTP mismatch showed more variability (R2=0.57, and R2=0.33, respectively). Based on FD-CTP, 16/20 (80%) patients met the inclusion criteria for MT according to the DEFUSE 3 perfusion criteria, in contrast to 18/20 (90%) patients based on conventional CTP. The vessel occlusion could be correctly extrapolated from the hypoperfusion in 18/20 cases (90%).
CONCLUSIONS
In our multicenter study, time-resolved whole brain FD-CTP was technically feasible, and qualitative and quantitative perfusion results correlated with those obtained with conventional CTP.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology |
UniBE Contributor: |
Kurmann, Christoph Carmelino, Kaesmacher, Johannes, Mordasini, Pasquale Ranato |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1759-8486 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
11 Apr 2022 09:22 |
Last Modified: |
16 Mar 2023 00:11 |
Publisher DOI: |
10.1136/neurintsurg-2021-018464 |
PubMed ID: |
35396333 |
Uncontrolled Keywords: |
CT perfusion Stroke Thrombectomy |
BORIS DOI: |
10.48350/169192 |
URI: |
https://boris.unibe.ch/id/eprint/169192 |
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