Hadizamani, Yalda; Anastasi, Stefano; Schori, Anouk; Lucas, Rudolf; Garweg, Justus G; Hamacher, Jürg (2023). Pathophysiological Considerations in Periorbital Necrotizing Fasciitis: A Case Report. Ocular immunology and inflammation, 31(2), pp. 468-473. Taylor & Francis 10.1080/09273948.2022.2032190
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BACKGROUND
Periorbital necrotizing fasciitis (PNF) is a rare complication of bacterial infection, associated with irreversible inflammatory destruction of soft tissues like subcutaneous tissue and superficial fascia. PNF can cause visual loss, septic shock and death within hours to days. Since the infection progresses rapidly from a local disease to septic shock, prompt identification and decisive interventions are mandatory.
AIM
Considering pathophysiology, differential diagnosis, and treatment options, we report a case of PNF and its outcome.Methods: A 69 years old male with febrile periorbital swelling had been diagnosed with bilateral PNF, caused by dual infection with Streptococcus pyogenes (S. pyogenes) and Staphylococcus aureus (S. aureus) based on conjunctival swabs.
RESULTS
The superantigens produced by S. pyogenes have been identified as key to the rapid dissemination of infection and severity of systemic manifestations.
CONCLUSIONS
A combination of intravenous antibiotics and regular surgical debridements resulted in a beneficial outcome in our patient.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Garweg, Justus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1744-5078 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
12 Apr 2022 09:41 |
Last Modified: |
17 Feb 2023 00:11 |
Publisher DOI: |
10.1080/09273948.2022.2032190 |
PubMed ID: |
35404751 |
Uncontrolled Keywords: |
Periorbital necrotizing fasciitis Staphylococcus aureus Streptococcus pyogenes antibiotic superantigens surgical debridement toxic shock syndrome |
BORIS DOI: |
10.48350/169219 |
URI: |
https://boris.unibe.ch/id/eprint/169219 |
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