No optical coherence tomography changes in premanifest Huntington's disease mutation carriers far from disease onset.

Schmid, Rahel Dominique; Remlinger, Jana; Abegg, Mathias; Hoepner, Robert; Hoffmann, Rainer; Lukas, Carsten; Saft, Carsten; Salmen, Anke (2022). No optical coherence tomography changes in premanifest Huntington's disease mutation carriers far from disease onset. Brain and Behavior, 12(6), e2592. Wiley 10.1002/brb3.2592

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BACKGROUND

Spectral-domain optical coherence tomography (OCT) may detect retinal changes as a biomarker in neurodegenerative diseases like manifest Huntington's disease (HD). We investigate macular retinal layer thicknesses in a premanifest HD (pre-HD) cohort and healthy controls (HC).

METHODS

Pre-HD mutation carriers underwent standardized ratings and a preset macular OCT scan. Thickness values were determined for each sector of all macular retinal layers, the mean of all sectors and the mean of the inner ring (IR, 3 mm) after segmentation (Heyex segmentation batch). HC were retrospectively included from an existing database. The IR thickness of the ganglion cell layer (GCL), retinal nerve fiber layer (RNFL), GCL + inner plexiform layer (GCIPL), and total retina were included in the exploratory correlation analyses with paraclinical ratings and compared to HC.

RESULTS

The analyses comprised n = 24 pre-HD participants (n = 10 male, n = 14 female) and n = 38 HC (n = 14 male, n = 24 female). Retinal layer parameters did not correlate with paraclinical ratings. Expected correlations between established HD biomarkers were robust. The IR thicknesses of the GCL, GCIPL, and total retina did not differ between pre-HD and HC. The IR thickness of the RNFL was significantly higher in pre-HD participants (pre-HD: 23.22 μm (standard deviation 2.91), HC: 21.26 μm (1.90), p = .002).

DISCUSSION

In this cross-sectional cohort of genetically determined pre-HD participants, neurodegenerative features were not detected with retinal layer segmentation. Since our pre-HD collective was more than 16 years before disease onset, OCT may not be sensitive enough to detect early changes.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Remlinger, Jana Silke; Abegg, Mathias; Hoepner, Robert and Salmen, Anke

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2162-3279

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

06 May 2022 09:49

Last Modified:

25 Jun 2022 00:14

Publisher DOI:

10.1002/brb3.2592

PubMed ID:

35511084

Uncontrolled Keywords:

Huntington's disease biomarker neurodegeneration optical coherence tomography retinal changes

BORIS DOI:

10.48350/169768

URI:

https://boris.unibe.ch/id/eprint/169768

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