Inflammatory Mediators in Atherosclerotic Vascular Remodeling.

Evans, Bryce R; Yerly, Anaïs; van der Vorst, Emiel P C; Baumgartner, Iris; Bernhard, Sarah Maike; Schindewolf, Marc; Döring, Yvonne (2022). Inflammatory Mediators in Atherosclerotic Vascular Remodeling. Frontiers in cardiovascular medicine, 9, p. 868934. Frontiers 10.3389/fcvm.2022.868934

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Atherosclerotic vascular disease remains the most common cause of ischemia, myocardial infarction, and stroke. Vascular function is determined by structural and functional properties of the arterial vessel wall, which consists of three layers, namely the adventitia, media, and intima. Key cells in shaping the vascular wall architecture and warranting proper vessel function are vascular smooth muscle cells in the arterial media and endothelial cells lining the intima. Pathological alterations of this vessel wall architecture called vascular remodeling can lead to insufficient vascular function and subsequent ischemia and organ damage. One major pathomechanism driving this detrimental vascular remodeling is atherosclerosis, which is initiated by endothelial dysfunction allowing the accumulation of intimal lipids and leukocytes. Inflammatory mediators such as cytokines, chemokines, and modified lipids further drive vascular remodeling ultimately leading to thrombus formation and/or vessel occlusion which can cause major cardiovascular events. Although it is clear that vascular wall remodeling is an elementary mechanism of atherosclerotic vascular disease, the diverse underlying pathomechanisms and its consequences are still insufficiently understood.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Angiologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Evans, Bryce Ridley; Yerly, Anaïs Elodie; Baumgartner, Iris; Bernhard, Sarah Maike; Schindewolf, Marc and Döring, Yvonne

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2297-055X

Publisher:

Frontiers

Language:

English

Submitter:

Pubmed Import

Date Deposited:

24 May 2022 14:21

Last Modified:

05 Jun 2022 01:57

Publisher DOI:

10.3389/fcvm.2022.868934

PubMed ID:

35600479

Uncontrolled Keywords:

atherosclerosis chemokines cytokines inflammatory mediator remodeling

BORIS DOI:

10.48350/170210

URI:

https://boris.unibe.ch/id/eprint/170210

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