Review: Vascular effects of PPARs in the context of NASH.

Guixé-Muntet, Sergi; Biquard, Louise; Szabo, Gyongyi; Dufour, Jean-François; Tacke, Frank; Francque, Sven; Rautou, Pierre-Emmanuel; Gracia-Sancho, Jordi (2022). Review: Vascular effects of PPARs in the context of NASH. Alimentary pharmacology & therapeutics, 56(2), pp. 209-223. Wiley-Blackwell 10.1111/apt.17046

[img]
Preview
Text
Aliment_Pharmacol_Ther_-_2022_-_Guix__Muntet_-_Review_Vascular_effects_of_PPARs_in_the_context_of_NASH.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (1MB) | Preview

BACKGROUND

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors known to regulate glucose and fatty acid metabolism, inflammation, endothelial function and fibrosis. PPAR isoforms have been extensively studied in metabolic diseases, including type 2 diabetes and cardiovascular diseases. Recent data extend the key role of PPARs to liver diseases coursing with vascular dysfunction, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).

AIM

This review summarises and discusses the pathobiological role of PPARs in cardiovascular diseases with a special focus on their impact and therapeutic potential in NAFLD and NASH.

RESULTS AND CONCLUSIONS

PPARs may be attractive for the treatment of NASH due to their liver-specific effects but also because of their efficacy in improving cardiovascular outcomes, which may later impact liver disease. Assessment of cardiovascular disease in the context of NASH trials is, therefore, of the utmost importance, both from a safety and efficacy perspective.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Dufour, Jean-François, Gracia Sancho, Jorge Sergio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0269-2813

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Pubmed Import

Date Deposited:

08 Jun 2022 08:50

Last Modified:

05 Dec 2022 16:20

Publisher DOI:

10.1111/apt.17046

PubMed ID:

35661191

BORIS DOI:

10.48350/170476

URI:

https://boris.unibe.ch/id/eprint/170476

Actions (login required)

Edit item Edit item
Provide Feedback