Capodanno, Davide; Baber, Usman; Bhatt, Deepak L; Collet, Jean-Philippe; Dangas, George; Franchi, Francesco; Gibson, C Michael; Gwon, Hyeon-Cheol; Kastrati, Adnan; Kimura, Takeshi; Lemos, Pedro A; Lopes, Renato D; Mehran, Roxana; O'Donoghue, Michelle L; Rao, Sunil V; Rollini, Fabiana; Serruys, Patrick W; Steg, Philippe G; Storey, Robert F; Valgimigli, Marco; ... (2022). P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention. Nature reviews - cardiology, 19(12), pp. 829-844. Nature Publishing Group 10.1038/s41569-022-00725-6
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For 20 years, dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and a platelet P2Y12 receptor inhibitor, has been the gold standard of antithrombotic pharmacology after percutaneous coronary intervention (PCI). In the past 5 years, several investigations have challenged this paradigm by testing the efficacy and safety of P2Y12 inhibitor monotherapy (that is, without aspirin) following a short course of DAPT. Collectively, these studies suggested a reduction in the risk of major bleeding and no significant increase in thrombotic or ischaemic events compared with guideline-recommended DAPT. Current recommendations are evolving to inform clinical practice on the ideal candidates for P2Y12 inhibitor monotherapy after PCI. Generalizing the results of studies of P2Y12 inhibitor monotherapy requires a thorough understanding of their design, populations, interventions, comparators and results. In this Review, we provide an up-to-date overview on the use of P2Y12 inhibitor monotherapy after PCI, including supporting pharmacodynamic and clinical evidence, practical recommendations and future directions.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Windecker, Stephan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1759-5010 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
15 Jun 2022 10:25 |
Last Modified: |
05 Dec 2022 16:20 |
Publisher DOI: |
10.1038/s41569-022-00725-6 |
PubMed ID: |
35697777 |
BORIS DOI: |
10.48350/170670 |
URI: |
https://boris.unibe.ch/id/eprint/170670 |
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