P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention.

Capodanno, Davide; Baber, Usman; Bhatt, Deepak L; Collet, Jean-Philippe; Dangas, George; Franchi, Francesco; Gibson, C Michael; Gwon, Hyeon-Cheol; Kastrati, Adnan; Kimura, Takeshi; Lemos, Pedro A; Lopes, Renato D; Mehran, Roxana; O'Donoghue, Michelle L; Rao, Sunil V; Rollini, Fabiana; Serruys, Patrick W; Steg, Philippe G; Storey, Robert F; Valgimigli, Marco; ... (2022). P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention. Nature reviews - cardiology, 19(12), pp. 829-844. Nature Publishing Group 10.1038/s41569-022-00725-6

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For 20 years, dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and a platelet P2Y12 receptor inhibitor, has been the gold standard of antithrombotic pharmacology after percutaneous coronary intervention (PCI). In the past 5 years, several investigations have challenged this paradigm by testing the efficacy and safety of P2Y12 inhibitor monotherapy (that is, without aspirin) following a short course of DAPT. Collectively, these studies suggested a reduction in the risk of major bleeding and no significant increase in thrombotic or ischaemic events compared with guideline-recommended DAPT. Current recommendations are evolving to inform clinical practice on the ideal candidates for P2Y12 inhibitor monotherapy after PCI. Generalizing the results of studies of P2Y12 inhibitor monotherapy requires a thorough understanding of their design, populations, interventions, comparators and results. In this Review, we provide an up-to-date overview on the use of P2Y12 inhibitor monotherapy after PCI, including supporting pharmacodynamic and clinical evidence, practical recommendations and future directions.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Windecker, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1759-5010

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Pubmed Import

Date Deposited:

15 Jun 2022 10:25

Last Modified:

05 Dec 2022 16:20

Publisher DOI:

10.1038/s41569-022-00725-6

PubMed ID:

35697777

BORIS DOI:

10.48350/170670

URI:

https://boris.unibe.ch/id/eprint/170670

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