Effects of 10-kHz Subthreshold Stimulation on Human Peripheral Nerve Activation.

Deletis, Vedran; Shils, Jay; Anso, Juan; Villar Ortega, Eduardo; Marchal-Crespo, Laura; Buetler, Karin A; Raabe, Andreas; Seidel, Kathleen (2023). Effects of 10-kHz Subthreshold Stimulation on Human Peripheral Nerve Activation. Neuromodulation: technology at the neural interface, 26(3), pp. 614-619. Elsevier 10.1016/j.neurom.2022.04.051

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OBJECTIVE

The mechanisms of action of high-frequency stimulation (HFS) are unknown. We investigated the possible mechanism of subthreshold superexcitability of HFS on the excitability of the peripheral nerve.

MATERIALS AND METHODS

The ulnar nerve was stimulated at the wrist in six healthy participants with a single (control) stimulus, and the responses were compared with the responses to a continuous train of 5 seconds at frequencies of 500 Hz, 2.5 kHz, 5 kHz, and 10 kHz. Threshold intensity for compound muscle action potential (CMAP) was defined as intensity producing a 100-μV amplitude in ten sequential trials and "subthreshold" as 10% below the CMAP threshold. HFS threshold was defined as stimulation intensity eliciting visible tetanic contraction.

RESULTS

Comparing the threshold of single pulse stimulation for eliciting CMAP vs threshold for HFS response and pooling data at different frequencies (500 Hz-10 kHz) revealed a significant difference (p = 0.00015). This difference was most obvious at 10 kHz, with a mean value for threshold reduction of 42.2%.

CONCLUSIONS

HFS with a stimulation intensity below the threshold for a single pulse induces axonal superexcitability if applied in a train. It can activate the peripheral nerve and produce a tetanic muscle response. Subthreshold superexcitability may allow new insights into the mechanism of HFS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Organs-on Chip Technologies
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Image Guided Therapy

UniBE Contributor:

Anso, Juan, Villar Ortega, Eduardo Enrique, Marchal Crespo, Laura, Bütler, Karin, Raabe, Andreas, Seidel, Kathleen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1094-7159

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

22 Jun 2022 15:09

Last Modified:

09 Apr 2023 00:11

Publisher DOI:

10.1016/j.neurom.2022.04.051

PubMed ID:

35715282

Uncontrolled Keywords:

10-kHz stimulation high-frequency stimulation peripheral nerve subthreshold superexcitability

BORIS DOI:

10.48350/170805

URI:

https://boris.unibe.ch/id/eprint/170805

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