Investigational drugs in early clinical development for portal hypertension.

Gomes Rodrigues, S; Mendoza, Yuly P; Bosch, Jaime (2022). Investigational drugs in early clinical development for portal hypertension. Expert opinion on investigational drugs, 31(8), pp. 825-842. Taylor & Francis 10.1080/13543784.2022.2095259

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INTRODUCTION

Advanced chronic liver disease is considered a reversible condition after removal of the primary aetiological factor. This has led to a paradigm shift in which portal hypertension (PH) is a reversible complication of cirrhosis. The pharmacologic management of PH is centered on finding targets to modify the natural history of cirrhosis and PH.

AREAS COVERED

This paper offers an overview of the use of pharmacological strategies in early clinical development that modify PH. Papers included were selected from searching clinical trials sites and PubMed from the last 10 years.

EXPERT OPINION

A paradigm shift has generated a new concept of PH in cirrhosis as a reversible complication of a potentially curable disease. Decreasing portal pressure to prevent decompensation and further complications of cirrhosis that may lead liver transplantation or death is a goal. Therapeutic strategies also aspire achieve total or partial regression of fibrosis thus eliminating the need for treatment or screening of PH.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Gomes Rodrigues, Susana, Mendoza Jaimes, Yuly Paulin, Bosch Genover, Jaime

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1744-7658

Publisher:

Taylor & Francis

Language:

English

Submitter:

Pubmed Import

Date Deposited:

28 Jun 2022 09:24

Last Modified:

02 Mar 2023 23:36

Publisher DOI:

10.1080/13543784.2022.2095259

PubMed ID:

35758843

Uncontrolled Keywords:

chronic liver disease cirrhosis hepatic hepatic venous pressure gradient portal pressure

URI:

https://boris.unibe.ch/id/eprint/170964

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