Winter, Babette L; Hovaguimian, Frédérique; Kouyos, Roger D; Schmidt, Axel Jeremias; Bernasconi, Enos; Braun, Dominique L; Calmy, Alexandra; Notter, Julia; Stoeckle, Marcel; Surial, Bernard; Christinet, Vanessa; Cavassini, Matthias; Depmeier, Carsten; Läuchli, Severin; Boffi El Amari, Emmanuelle; Reinacher, Matthias; Rasi, Manuela; Bruggmann, Philip; Haerry, David; Bize, Raphaël; ... (2022). Changes in mental and sexual health among MSM using HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: longitudinal analysis of the SwissPrEPared cohort study. Swiss medical weekly, 152, w30192. EMH Schweizerischer Ärzteverlag 10.4414/smw.2022.w30192
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BACKGROUND
Changes in mental and sexual health among men having sex with men (MSM) due to the SARS-CoV-2 pandemic remain unclear.
METHODS
Design: Longitudinal analysis of an ongoing, multicentre, pre-exposure prophylaxis (PrEP) cohort (NCT03893188) in Switzerland. Participants: HIV-negative MSM aged ≥18 who completed at least one questionnaire before and one after the start of the SARS-CoV-2 pandemic. Outcomes: Primary: mental health, defined as anxiety and depression scores assessed by the Patient Health Questionnaire-4. Secondary: sexual behaviour, well-being, PrEP use and disruption of care. Outcomes were assessed over seven periods corresponding to different SARS-CoV-2 prevention measures in Switzerland. We performed pairwise comparisons between periods (Wilcoxon signed rank test).
RESULTS
Data from 1,043 participants were included. Whilst anxiety scores remained stable over time, depression scores worsened in the second wave and the second lockdown period compared to pre-pandemic scores. This was confirmed by pairwise comparisons (pre-SARS-CoV-2/second wave and pre-SARS-CoV-2/second lockdown: p <0.001). Downward trends in sexual activity,sexualized substance use, and a switch from daily to "event-driven" PrEP were found. Disruption of care affected 42.6% (790/1856) of daily PrEP users' follow-up visits.
CONCLUSION
In this longitudinal analysis of a PrEP cohort enrolling MSM, depression scores worsened in the second wave and the second lockdown compared to the pre-pandemic period.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Surial, Bernard, Low, Nicola |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1424-7860 |
Publisher: |
EMH Schweizerischer Ärzteverlag |
Funders: |
[191] Swiss Federal Office of Public Health = Bundesamt für Gesundheit ; [4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Jun 2022 11:39 |
Last Modified: |
05 Dec 2022 16:21 |
Publisher DOI: |
10.4414/smw.2022.w30192 |
PubMed ID: |
35758418 |
BORIS DOI: |
10.48350/170967 |
URI: |
https://boris.unibe.ch/id/eprint/170967 |
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