Karousis, Evangelos D; Mühlemann, Oliver (2022). The broader sense of nonsense. Trends in biochemical sciences, 47(11), pp. 921-935. Elsevier Current Trends 10.1016/j.tibs.2022.06.003
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Nonsense-mediated mRNA decay (NMD) serves as a quality control mechanism by degrading mRNAs with premature termination codons (PTCs), and it also regulates the abundance of physiological RNAs encoding functional proteins.
Recent work showed that NMD can be triggered with a certain probability by each translation termination event.
Readthrough of the PTC can render NMD-sensitive mRNA molecules immune to NMD, which can explain why a certain fraction of an otherwise NMD-sensitive mRNA population persists.
Accurate prediction of NMD-sensitive transcripts based on sequence information is currently not possible; experimental testing is necessary.
NMD modulates the severity of many genetic diseases and affects antigen presentation in cancer cells and the progression of developmental diseases.
NMD targets many viral RNAs, but viruses circumvent this by expressing NMD-inhibiting proteins and harboring NMD-suppressing sequence elements in their RNAs.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Karousis, Evangelos, Mühlemann, Oliver |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry 000 Computer science, knowledge & systems |
ISSN: |
0968-0004 |
Publisher: |
Elsevier Current Trends |
Language: |
English |
Submitter: |
Christina Schüpbach |
Date Deposited: |
30 Jun 2022 07:38 |
Last Modified: |
05 Dec 2022 16:21 |
Publisher DOI: |
10.1016/j.tibs.2022.06.003 |
BORIS DOI: |
10.48350/171009 |
URI: |
https://boris.unibe.ch/id/eprint/171009 |
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