The broader sense of nonsense

Karousis, Evangelos D; Mühlemann, Oliver (2022). The broader sense of nonsense. Trends in biochemical sciences, 47(11), pp. 921-935. Elsevier Current Trends 10.1016/j.tibs.2022.06.003

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Nonsense-mediated mRNA decay (NMD) serves as a quality control mechanism by degrading mRNAs with premature termination codons (PTCs), and it also regulates the abundance of physiological RNAs encoding functional proteins.

Recent work showed that NMD can be triggered with a certain probability by each translation termination event.

Readthrough of the PTC can render NMD-sensitive mRNA molecules immune to NMD, which can explain why a certain fraction of an otherwise NMD-sensitive mRNA population persists.

Accurate prediction of NMD-sensitive transcripts based on sequence information is currently not possible; experimental testing is necessary.

NMD modulates the severity of many genetic diseases and affects antigen presentation in cancer cells and the progression of developmental diseases.

NMD targets many viral RNAs, but viruses circumvent this by expressing NMD-inhibiting proteins and harboring NMD-suppressing sequence elements in their RNAs.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Karousis, Evangelos, Mühlemann, Oliver

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
000 Computer science, knowledge & systems

ISSN:

0968-0004

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

30 Jun 2022 07:38

Last Modified:

05 Dec 2022 16:21

Publisher DOI:

10.1016/j.tibs.2022.06.003

BORIS DOI:

10.48350/171009

URI:

https://boris.unibe.ch/id/eprint/171009

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