Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence.

Eloiflin, Roger-Junior; Grau-Roma, Llorenç; Python, Sylvie; Mehinagic, Kemal; Godel, Aurélie; Libeau, Geneviève; Summerfield, Artur; Bataille, Arnaud; García-Nicolás, Obdulio (2022). Comparative pathogenesis of peste des petits ruminants virus strains of difference virulence. Veterinary research, 53(1), p. 57. BioMed Central 10.1186/s13567-022-01073-6

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Peste des petits ruminants (PPR) is an acute disease of small ruminants caused by a morbillivirus. Clinical observation of the disease in the field revealed that several species of small ruminants are affected to varying degrees. This difference in disease-related effects could depend either on the host or on the virulence of the virus strain. A previous study highlighted the difference in virulence between two strains of PPRV used to infect Saanen goats. For this breed, PPRV Morocco 2008 strain (MA08) was highly virulent while PPRV Côte d'Ivoire 1989 (IC89) strain induced mild disease. Experimental studies generally based on healthy and young animals do not permit exploration of the natural variability of the host susceptibility to PPRV. Therefore, building on the previous study on Saanen goats, the current study focussed on this breed of goat and used commercially available animals with an unknown history of infection with other pathogens. Results confirmed the previous disease pattern for PPRV IC89 and MA08 strains. Viral RNA detection, macroscopic and histological lesions were stronger for the highly virulent MA08 strain. We show here for the first time that viral RNA can be detected in the tissues of vaccinated animals. Viral RNA was also detected for the first time in serum samples, which is in agreement with the role of circulating immune cells in transporting the virus into host target organs. Thus, this study provides insight into the pathogenesis of strains of different virulence of PPRV and will help to better understand the onset of the disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Virology and Immunology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Grau Roma, Llorenç, Mehinagic, Kemal, Godel, Aurélie, Summerfield, Artur, Garcia Nicolas, Obdulio

Subjects:

600 Technology > 630 Agriculture

ISSN:

1297-9716

Publisher:

BioMed Central

Language:

English

Submitter:

Pubmed Import

Date Deposited:

11 Jul 2022 10:34

Last Modified:

05 Dec 2022 16:21

Publisher DOI:

10.1186/s13567-022-01073-6

PubMed ID:

35804440

Uncontrolled Keywords:

Peste des petits ruminants pathogenesis virulence

BORIS DOI:

10.48350/171216

URI:

https://boris.unibe.ch/id/eprint/171216

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